皮层厚度可以缓和老年人前额叶皮层激活模式的个体内变化,在行走期间
Daliah Ross1, Mark E Wagshul2, Meltem Izzetoglu3
1Ferkauf Graduate School of Psychology, Yeshiva University, Bronx, NY, USA.
概括
老年人皮层厚度的降低与双重任务行走期间大脑氧化率更大的变化有关. 这种神经效率低下可能是未来移动性问题的信号.
科学领域:
- 神经科学是一个神经科学.
- 衰老研究研究 衰老研究
- 认知科学 认知科学
背景情况:
- 在认知任务中增加个体内变异性 (IIV) 是已知的不良结果的风险因素.
- 血液动力学信号IIV的研究,特别是与衰老和皮质结构相关的研究,是有限的.
- 老年人双重任务行走 (DTW) 的表现与认知功能和神经完整性有关.
研究的目的:
- 在健康的老年人中,调查皮层厚度和前额叶皮层氧化血红蛋白 (HbO2) 在DTW期间的IIV之间的联系.
- 为了确定皮质厚度的减少是否与从单个任务到DTW增加的HbO2 IIV有关.
- 探索神经效率低下在衰老和移动性中的作用.
主要方法:
- 研究包括55名健康的老年人 (平均年龄74.84岁).
- 使用结构性MRI量化皮质厚度.
- 在行走时前额叶皮层的HbO2变化使用功能近红外光谱学 (fNIRS) 进行了评估.
- 计算HbO2 IIV是每项任务最初30秒期间HbO2观测的标准偏差.
- 线性混合模型检查了皮质厚度对HbO2 IIV的适度效应.
主要成果:
- 几个大脑区域的皮层厚度较薄与HbO2 IIV从单项任务到DTW (p < .02) 的较大增加显著相关.
结论:
- 皮层厚度减少,特别是在前额叶皮层,与DTW期间HbO2 IIV增加有关,这表明神经效率低下.
- 这种关联在没有相应的行为益处的情况下被观察到,突出显示了大脑活动和表现之间的潜在断开.
- 减少皮层厚度和更大的前额叶皮层HbO2 IIV可能成为老年人发展移动障碍的潜在风险因素.
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