在患有动脉高血压的患者中,表面结节和增加血管不良事件风险之间的关联
Jiule Ding1, Jie Chen1, Jun Zhou1
1Department of Radiology, The Third Affiliated Hospital of Soochow Univesity, Changzhou, Jiangsu, China.
概括
通过CT扫描检测到的表面结节性 (RSN) 与高血压患者的血管不良事件 (AVE) 风险更高有关. 这一发现凸显了RSN作为该人群中心血管风险的潜在指标.
科学领域:
- 腎臟病學 (nephrology) 是一種醫學專業.
- 放射学 放射学是一门学科.
- 心血管医学 心血管医学
背景情况:
- 动脉高血压是血管不良事件 (AVE) 的主要危险因素.
- 表面结节性 (RSN) 是脏的形态变化,通常使用计算机断层扫描 (CT) 进行评估.
- 在高血压患者中,RSN和AVE风险之间的联系需要进一步调查.
研究的目的:
- 在被诊断为动脉高血压的患者中,研究表面结节 (RSN) 和血管不良事件 (AVE) 风险之间的关系.
- 确定RSN的定性 (半RSN) 和定量 (qRSN) 测量是否可以预测高血压患者的AVE.
主要方法:
- 一项涉及182名高血压患者 (年龄在18-60岁) 的横截面研究,这些患者在2012年至2020年期间接受了增强对比度的脏CT扫描.
- 患者被分为AVE (n=91) 和非AVE (n=91) 组,根据年龄和性别进行匹配.
- 使用定性 (半RSN) 和定量 (qRSN) 方法评估RSN;收集了包括血压和并发症在内的临床数据.
主要成果:
- 与非AVE组相比,AVE组表现出较低的年龄,较高的缩血压 (SBP),以及较低的糖尿病和高脂血症患病率 (P < .01).
- 阳性半RSN在AVE组的频率明显高 (49.45%对14.29%,P <.001).
- 在AVE组中,定量RSN (qRSN) 显著更大 [1.03 (0.85,1.33) 与0.86 (0.75,1.03),P < .001].
- 半RSN (OR=7.04,P <.001) 和qRSN (OR=5.09,P =.003) 两种独立地与增加的AVE风险相关.
- 将临床特征与RSN测量相结合的模型显示,与单独RSN测量相比,AVE的预测准确度提高了 (AUC,P ≤ .01).
结论:
- 基于CT成像的表面结节性 (RSN) 评估与患有动脉高血压的成年患者的血管不良事件 (AVE) 风险增加有关.
- 质量和数量评估的RSN作为一个有价值的成像生物标志物,用于预测高血压患者的AVE.
- 将RSN评估整合到常规CT评估中可能有助于对高血压患者的心血管风险进行分层.
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