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DNA 序列与蛋白质序列同样有用,可以推断出深层次的族系

Paschalia Kapli¹, Ioanna Kotari^1,2, Maximilian J Telford¹

¹Department of Genetics, University College London, Gower Street, London WC1E 6BT, UK.

Systematic biology

|June 27, 2023

概括

DNA 序列可能与蛋白质序列一样有效,用于推断深层的族系. 这一发现挑战了长期以来的信念,并表明DNA数据分析为进化研究提供了计算优势.

科学领域:

进化生物学是进化的生物学.
生物信息学是一种生物信息学.
计算型的遗传学学.

背景情况:

深层遗传学推断传统上倾向于蛋白质序列而不是DNA,因为人们认为同位素和和率较低.
对DNA序列的构成异质性的担忧在历史上限制了它们在深度遗传学分析中的使用.

研究的目的:

挑战普遍认为蛋白质序列优于DNA序列的普遍观念,以深入推断遗传学.
用各种进化模型评估DNA和蛋白质序列在重建深层族系时的有用性.

主要方法:

在理想化的遗传密码下,使用密码进化模型进行了一项模拟研究.
蛋白质编码数据是通过整合跨站点和谱系的异质替代过程来生成的.
在模拟和实证元动物数据上使用核酸,氨基酸和子替代模型进行了分析.

主要成果:

使用核酸替代模型对DNA序列的分析恢复了正确的基因组,以及使用氨基酸模型进行蛋白质序列分析.
模拟和实证数据分析都表明,DNA序列与蛋白质序列相似,用于深层次的基因推断.
在核酸模型下进行的DNA数据分析表明,与蛋白质数据分析相比,具有显著的计算优势.

结论:

DNA 序列与蛋白质序列同样有价值,可以推断出深层的族系,因此不应该被排除在此类分析之外.
在遗传学推断中对DNA序列的感知限制可能是误解.
DNA数据分析的计算效率有助于应用先进的遗传学重建模型.

关键词:

氨基酸模型氨基酸模型码头模型的模型深层的原始物种学.不同质的过程是不同质的过程.核酸替代是核酸替代的方法之一.遗传学上的信息遗传学上的信息

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