[血压指数与败血症患者的预后之间的相关性:基于MIMIC-III数据库的队列研究]
Xiaobin Liu1, Yu Zhao2, Yingyi Qin3
1Department of Burns, Changhai Hospital of Naval Medical University, Shanghai 200433, China.
Zhonghua wei zhong bing ji jiu yi xue
|June 27, 2023
概括
早期的血压指数可以显著预测败血症患者的预后. 一个开发的诺莫格拉姆模型准确地预测了28天的存活率,突出了平均动脉压和透气指数的重要性.
科学领域:
- 关键护理医学 关键护理医学
- 心血管生理学心血管生理学
- 生物统计学 生物统计学
背景情况:
- 败血症是一种危及生命的器官功能障碍,是由宿主对感染的反应失调引起的.
- 早期识别败血症的预后因素对于及时干预和改善患者结果至关重要.
- 血液动力学参数,包括血压,是重症患者循环功能的重要指标.
研究的目的:
- 研究早期血压指数与败血症患者的预后之间的相关性.
- 开发和验证28天败血症死亡率的预测模型.
主要方法:
- 使用MIMIC-III数据库 (2001-2012) 进行的回顾性队列研究.
- 包括11,559名败血症患者,根据28天的预后分为生存和死亡组.
- 开发多变量逻辑回归模型和名图,使用ROC,PRC和DCA曲线进行验证.
主要成果:
- 生存和死亡组之间的人口和临床变量的显著差异.
- 发现的关键预测因素包括心率,最大平均动脉压指数,平均和中位动脉压指数,以及中位动脉压指数.
- 开发的诺莫格拉姆模型表现出对28天败血症预后的良好预测准确性和校准.
结论:
- 早期血压指数是败血症患者28天预后的重要预测指标.
- 合并这些索引的经过验证的名录模型为预测败血症结果提供了可靠的工具.
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