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相关概念视频

Parkinson's Disease: Overview01:15

Parkinson's Disease: Overview

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Neurodegenerative disorders are progressive diseases that cause irreversible damage and loss to neurons in specific brain areas. Examples of these disorders include Parkinson's disease, Alzheimer's disease, Multiple Sclerosis (MS), and Amyotrophic Lateral Sclerosis (ALS). These disorders share characteristics such as proteinopathies, selective neuronal vulnerability, and a complex interplay between genetic and environmental factors. The primary therapeutic goal for these conditions is...
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Human Genetics01:28

Human Genetics

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Human genetics provides a profound framework for understanding the interplay between genetic predispositions and human psychology. At the heart of this discipline lies the study of how genes influence physical traits, behaviors, and susceptibility to diseases. Each person carries a unique genetic code that subtly or significantly shapes their psychological and behavioral landscape.
The complex relationship between genetics and psychology is observable through common biological components such...
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Parkinson's Disease: Treatment01:24

Parkinson's Disease: Treatment

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Neurodegenerative disorders, such as Parkinson's Disease (PD), involve the gradual and irreversible destruction of neurons in particular brain areas. These disorders exhibit standard features like proteinopathies, selective vulnerability of some neurons, and an interaction of intrinsic properties, genetics, and environmental influences in neural injury.
Parkinson's Disease is primarily a result of the loss of dopaminergic neurons in the substantia nigra pars compacta. The cornerstone of...
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Biological Causes of Schizophrenia01:29

Biological Causes of Schizophrenia

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Schizophrenia, a severe psychiatric disorder, arises from a complex interplay of biological factors, including genetic predisposition, structural brain abnormalities, neurotransmitter dysregulation, and developmental irregularities. These factors collectively contribute to the onset and progression of the disorder, which typically manifests in late adolescence or early adulthood.
Genetic Factors in Schizophrenia
The genetic basis of schizophrenia is strongly supported by family and twin...
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Psychosis: Pathophysiology of Schizophrenia and Other Psychotic Disorders01:27

Psychosis: Pathophysiology of Schizophrenia and Other Psychotic Disorders

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Schizophrenia is a neurodevelopmental disorder whose origins are rooted in complex genetic components. Despite our burgeoning understanding, the pathophysiology of this disorder remains incompletely deciphered.
Researchers have identified genetic factors that increase susceptibility to schizophrenia, underscoring the intricate interplay between genetics and environment in disease development. At the core of schizophrenia's pathophysiology is excessive dopaminergic neurotransmission within...
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Neural Regulation01:37

Neural Regulation

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Digestion begins with a cephalic phase that prepares the digestive system to receive food. When our brain processes visual or olfactory information about food, it triggers impulses in the cranial nerves innervating the salivary glands and stomach to prepare for food.
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相关实验视频

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Rab10 Phosphorylation Detection by LRRK2 Activity Using SDS-PAGE with a Phosphate-binding Tag
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帕金森病 - 遗传原因

Ajith Cherian1, Divya K P, Asish Vijayaraghavan

  • 1Department of Neurology, Sree Chitra Tirunal Institute for Medical Sciences and Technology, Trivandrum, Kerala, India.

Current opinion in neurology
|June 27, 2023
PubMed
概括

遗传突变是5-10%的帕金森病病例的原因,最近的发现突出了新的基因和途径. 了解这些遗传因素对于开发个性化医疗方法至关重要.

科学领域:

  • 遗传学 遗传学 是一个
  • 神经科学是一个神经科学.
  • 分子生物学分子生物学

背景情况:

  • 帕金森病 (PD) 的遗传学已经取得了重大进展,5-10%的病例归因于单一的原因.
  • 已知的遗传因素包括自体主导基因 (例如SNCA,LRRK2) 和衰退基因 (例如PRKN,PINK1,DJ-1) 的突变.
  • 最近的发现涉及像RIC3这样的新型基因,与胆固醇通路相关,以及其他如MAPT,TMEM230,LRP10,NUS1和ARSA.

结论:

  • 帕金森病的遗传发现正在迅速推进.
  • 验证新的基因是具有挑战性的,因为稀疏和广泛的受影响的家庭.
  • 未来的遗传洞察力将提高疾病预测,预后和帕金森病精准医学的发展.

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