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纤维细胞激活蛋白-α (FAP) 识别了结直肠新生病中的流体入侵

Alexandre Tarín-Nieto¹, Jon D Solano-Iturri^2,3, Inés Arrieta-Aguirre⁴

¹Department of Anatomic Pathology, Basurto University Hospital.

The American journal of surgical pathology

|June 27, 2023

概括

纤维细胞激活蛋白-α (FAP) 可以帮助区分侵袭性结肠直肠癌和腺瘤. 这种免疫组织化学标记物具有高度的特异性和灵敏性,有助于病理学家在内镜活检中诊断肌层侵袭.

科学领域:

胃肠病学胃肠病学
在瘤学瘤学.
病理学病理学病理学

背景情况:

全国范围的查增加了结直肠腺瘤和早期腺癌 (ADC) 的检测.
活检的组织病理学分析可能会产生关于 stromal 侵袭的不确的诊断.
准确的诊断对于适当的患者管理和治疗决策至关重要.

研究的目的:

为了评估纤维细胞激活蛋白-α (FAP) 免疫组织化学的诊断准确性.
要区分结肠直肠腺瘤 (低度发育不良[LGD]和高度发育不良[HGD]) 和侵入性ADC.
评估FAP在解决 stromal 侵袭的不确定的组织病理学诊断中的实用性.

主要方法:

对内镜活检样本的回顾性分析.
包括30个ADC,52个HGD和15个LGD.
用于FAP表达的免疫组织化学染色.

主要成果:

在30个侵袭性ADC中,23个 (76.7%) 观察到FAP表达.
在所有分析的LGD或HGD腺瘤中,FAP表达是负的 (100%的特异性).
FAP的曲线下的面积 (AUC) 为0.883 (95% CI:0.790.98).

结论:

FAP是一种高度特定的标记物,用于识别侵入性结直肠腺癌.
在内镜活检中,FAP免疫组织化学可以帮助病理学家区分侵袭性病变和腺瘤.
这种标记物可能有助于减少重复活检的需要,并提高诊断效率.

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