在婴儿饮食中引入果仁的可行性和安全性-一项随机试验
Debra J Palmer1,2, Desiree T Silva1,2,3,4, Susan L Prescott1,2,5,6
1Telethon Kids Institute, Nedlands, Western Australia, Australia.
概括
给6-8个月龄的婴儿,每周三次,一茶匙,介绍子,是安全的和可行的. 这种早期引入可能有助于预防果仁过敏,类似于花生引入指南.
科学领域:
- 儿科过敏和免疫学
- 婴儿营养 婴儿营养
- 食物过敏预防 预防食物过敏
背景情况:
- 目前的婴儿养指南建议早期引入花生,以减少过敏的流行率.
- 然而,缺乏关于树核的早期引入的证据,包括果仁.
- 这项研究旨在评估向婴儿传播子的安全性和可行性.
研究的目的:
- 确定特定剂量推的安全性和可行性,以引入豆传播给婴儿.
- 评估早期介绍南瓜在预防IgE介导的南瓜过敏方面的潜力.
主要方法:
- 一个平行,三臂,单盲随机对照试验,涉及6-8个月龄的婴儿.
- 婴儿被随机分配,每周三次接受一个茶匙 (干预1) 或增加剂量 (干预2) 的果仁,或没有具体建议 (控制).
- 通过食物挑战对过敏的评估是在1岁时进行的.
主要成果:
- 与增加剂量组 (79%) 相比,一茶匙组的遵守率更高 (92%).
- 一名婴儿经历了轻微的,延迟反应,但在1岁时没有发展果过敏.
- 只有一个对照婴儿,没有很早地接触到果仁,在1岁时发展出了果仁过敏.
结论:
- 从6-8个月开始,婴儿每周三次定期食用一茶匙麻豆,这是可行的和安全的.
- 早期引入果仁传播似乎是婴儿的安全策略.
- 这支持了类似策略的潜力,以预防婴儿的树核过敏.
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