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在婴儿期首次引入花生时对花生的反应与年龄≥8个月和湿疹的严重程度有关
Dirk H J Verhoeven1,2, Irene C E M Herpertz3, Jeroen Hol4
1Department of Pediatrics, Reinier de Graaf Hospital, Delft, The Netherlands.
概括
在8个月之前早期引入花生可以预防婴儿的过敏反应,特别是患有湿疹的婴儿. 对于患有严重湿疹的婴儿,建议在7个月内引入花生,以尽量减少风险.
科学领域:
- 儿科过敏学 儿科过敏学
- 免疫学 免疫学 免疫学
- 临床营养学 临床营养学
背景情况:
- 以前的研究表明,早期引入花生可以预防花生过敏.
- 由于先前排除了敏感婴儿,最佳时间尚不清楚.
研究的目的:
- 确定花生引入的最佳时间,以防止过敏反应.
- 调查在早期引入花生期间发生反应的危险因素.
主要方法:
- "花生NL"研究涉及6个荷兰儿科中心的707名婴儿.
- 婴儿在6个月左右接受了皮肤刺伤测试和口服花生挑战.
- 多变量分析确定年龄和湿疹严重程度是危险因素.
主要成果:
- 23%的婴儿对花生敏感;9.5%有积极的口腔挑战.
- 在≥8个月的婴儿中,引入花生增加了中度/重度湿疹的婴儿反应风险.
- 对于花生过敏和蛋反应的家族病史并不是独立的危险因素.
结论:
- 建议在8个月前引入花生,以减少中度至严重湿疹的婴儿的反应风险.
- 由于反应风险最高,建议在患有严重湿疹的婴儿7个月后进行临床引入.
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