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在一个种族多样化的社区献血者群体中,肝炎E病毒的阳性

Jordan K Mah¹, MeiLe Keck^1,2, Daniel Y Chu^1,2

¹Department of Pathology, Stanford University School of Medicine, Stanford, California, USA.

|June 27, 2023

概括

肝炎E病毒 (HEV) 查在当地血液供应中没有发现病毒性捐赠者,尽管IgG血清阳性率为12.1%. 目前不建议进行常规的HEV血液查,但建议定期监测.

科学领域:

输血医学输血医学
病毒学病毒学
传染性疾病传染性疾病

背景情况:

肝炎E病毒 (HEV) 是一种新兴的传染病,有可能危及血液供应安全.
输血相关的HEV感染的患病率和风险需要进行局部评估.

研究的目的:

为了确定当地的血液供应对HEV传播的易感性.
查献血血液中的HEV标记物,并确定血清阳性风险因素.

主要方法:

选了10002个献血人群的HEV RNA (RT-qPCR) 和抗体 (IgM/IgG) 的血液.
收集的捐赠者人口统计数据 (年龄,种族,居住地,旅行).
使用多变量逻辑回归来分析IgG血清阳性风险因素.

主要成果:

在任何捐赠中都没有检测到HEV RNA.
总体HEV IgG血清阳性为12.1%,IgM为0.56%. 这是一个很好的结果.
增加IgG血清阳性风险与年龄较大,白人/亚洲族裔以及特定的郡居住相关.

结论:

HEV IgG 血清流行率表明正在进行的局部 HEV 感染.
没有发现病毒性捐赠者,这表明目前没有通过输血传播HEV的风险.
目前不需要进行常规的HEV血液查,但建议进行持续监测.

关键词:

献血者血液供应安全供应安全多样化的献血者人口.乙型肝炎E型肝炎是什么?输血是输血的方法之一.输血传播的感染输血传播的感染

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