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脑下垂体瘤中的:78名患者的体质谱和预测分析
Xiu Wang1, Chang Liu1, Zhong Zheng2
1Department of Neurosurgery, Beijing Tian Tan Hospital, Capital Medical University, Beijing, 100070, China.
Annals of clinical and translational neurology
|June 27, 2023
概括
凝结性发作在下丘脑瘤 (HH) 患者中很常见,但发作类型随着时间的推移而演变. 较大的腹腔内HH病变与的更快进展相关,特定的病变类型增加自动化风险.
科学领域:
- 神经学 神经学
- 发病学 (Epileptology) 是一个专业的学科.
- 神经科学是一个神经科学.
背景情况:
- 脑下垂体瘤 (HH) 是一种与相关的罕见先天性瘤.
- 了解症的表征学和HH的演变对于患者管理至关重要.
研究的目的:
- 在大量患有下丘脑瘤的患者队列中,分析症状和疾病进展.
- 为了确定发作演变的预测因素和HH相关的特定半学.
主要方法:
- 对78名患有HH相关的患者的形学和医疗记录的回顾性审查.
- 单变量和二进制逻辑回归分析,以评估类型的预测因素.
主要成果:
- 凝结性发作是最常见的初始发作类型 (73.1%).
- 平均4.59年后,在68.4%的患者中出现了额外的发作类型,自动性,版本和通用性强力-克隆性发作变得越来越频繁.
- 腹腔内HH病变的大小与发作的演变持续时间负相关 (r = -0.445,p = 0.009).
- 与Dysembryoplastic Neuroepithelial Tumor (DF-II) HH病变患者的自动症发生率高于DF-III病变的患者 (p = 0.014).
结论:
- 凝结性发作在HH发作时是典型的,但随着疾病的进展,出现了不同的半理学.
- 腹腔内HH病变的大小是影响症演变的关键因素.
- 特定的HH病变类型 (DF-II) 与自动化发展的风险增加有关,影响了网络动态.
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