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在口腔膜状细胞癌中使用随机步行与障碍模型进行体内微观结构成像.

Yue Cao1,2,3, Siamak Nejad Davarani1, Daekeun You1

  • 1Department of Radiation Oncology, University of Michigan, Ann Arbor, Michigan, USA.

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概括

这项研究引入了依赖时间的扩散成像,使用短时间限制随机走路与障碍模型 (STL-RWBM) 来评估癌症对治疗的早期反应. 瘤体积与表面积比率 (V/S) 与口腔/腔状细胞癌的临床阶段相关.

关键词:
癌症成像检查 癌症成像检查微观结构成像成像技术口腔喉皮状细胞癌的发生.振荡梯度旋转回声回声振荡梯度旋转回声回声表面与体积的比率是表面与体积的比率.时间依赖的扩散图像.

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科学领域:

  • 在瘤学瘤学.
  • 放射学 放射学是指放射学
  • 生物物理学的生物物理.

背景情况:

  • 表面扩散系数 (ADC) 在检测瘤微观结构和治疗诱导的细胞变化方面是有限的.
  • 需要新的扩散成像技术来精确量化瘤特征和治疗反应.

研究的目的:

  • 用短时间限制随机走路与障碍模型 (STL-RWBM) 调查时间依赖的扩散成像.
  • 量化微观结构参数和早期癌症细胞对口腔/腔状细胞癌 (OPSCC/OCSCC) 治疗的反应.

主要方法:

  • 一项前性研究,涉及27名OPSCC/OCSCC患者,在化疗辐射治疗 (CRT) 之前和期间接受MRI.
  • 使用3TMRI与振荡梯度脊柱回声 (OGSE) 和脉冲梯度旋转回声 (PGSE) 序列.
  • 应用STL-RWBM以估计自由扩散系数 (D0),体积与表面积比 (V/S) 和细胞膜透率 (κ).

主要成果:

  • 推导的有效扩散时间对V/S和 κ估计产生了40%的影响.
  • 瘤V/S值与OPSCC/OCSCC中的临床阶段 (r=0.47) 有显著的相关性.
  • 早期CRT反应显示D0显著增加 (14%,P=0.03) 和 κ和V/S不显著增加.

结论:

  • 有效的扩散时间估计对于准确的微观结构参数量化至关重要.
  • 瘤V/S是一种潜在的成像生物标志物,与OPSCC/OCSCC的临床阶段相关.
  • 使用STL-RWBM的时间依赖扩散成像显示了早期治疗效果监测的前景.