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吸烟,咖啡消费,酒精摄入和阻塞性睡眠呼吸暂停:孟德尔的随机化研究

Yinghao Yang¹, Jinghao Wu¹, Shanshan Li¹

¹Department of Neurology, The First Affiliated Hospital of Zhengzhou University, No.1 Eastern Jianshe Road, Zhengzhou, 450052, Henan, China.

Current neurovascular research

|June 27, 2023

概括

基因预测的吸烟和较高的咖啡摄入量因果上增加了阻塞性睡眠呼吸暂停 (OSA) 的风险. 永不吸烟与OSA风险降低有关,这突出了生活方式因素对睡眠健康的影响.

科学领域:

遗传学遗传学是一个
睡眠医学睡眠医学
流行病学流行病学

背景情况:

阻塞性睡眠呼吸暂停 (OSA) 与吸烟和咖啡消费等生活方式因素有关.
以前的研究表明存在关联,但因果关系需要严格的调查.

研究的目的:

调查吸烟,饮酒和咖啡摄入对阻塞性睡眠呼吸暂停 (OSA) 的因果关系.
利用门德尔随机化 (MR) 建立这些行为和OSA发病率之间的潜在因果关系.

主要方法:

使用全基因组关联研究 (GWAS) 数据,采用两样本的门德尔随机化 (MR) 设计.
使用逆方差权衡 (IVW) 作为主要分析方法,使用替代MR技术进行灵敏度分析.
执行多变量MR (MVMR) 来调整包括BMI,高血压和糖尿病在内的共变量.

主要成果:

无变MR表示吸烟开始和咖啡摄入与增加OSA风险有关.
从未吸烟显示出对OSA的保护性关联.
对糖尿病和高血压的多变量MR调整支持从不吸烟的因果关系,但不是咖啡消费;对BMI的调整否定了观察到的因果关系.

结论:

基因预测的吸烟和较高的咖啡摄入量表明与阻塞性睡眠呼吸暂停 (OSA) 风险增加的因果关系.
这些发现强调了在OSA病因和管理中考虑吸烟和咖啡消费的重要性.

关键词:

吸烟吸烟吸烟吸烟酒精消费酒精消费酒精消费有关因果关系的因果关系咖啡的摄入量咖啡的摄入量门德尔的随机化是门德尔的随机化睡眠呼吸暂停 (Sleep Apnea) 是一个

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