在拉丁美洲以人口为基础的队列中,螺旋计图案,阻塞和PRISM的轨迹
Rogelio Perez-Padilla1, Maria Montes de Oca2, Ireri Thirion-Romero1
1National Institute of Respiratory Diseases, Mexico City, Mexico.
概括
维护比率受损螺旋计 (PRISm) 影响拉丁美洲5%的成年人,并与较高的死亡率有关. 这种情况是不稳定的,经常发展为COPD,强调需要仔细监测.
科学领域:
- 肺部医学 肺部医学
- 流行病学 流行病学
- 呼吸系统健康 呼吸系统健康
背景情况:
- 保留比率受损螺旋计 (PRISm) 与不良健康结果有关.
- 随着时间的推移,PRISM可能会发展到其他螺旋计分类.
- 在不同的人群中理解PRISm至关重要.
研究的目的:
- 为了确定拉丁美洲人口中PRISM的流行率.
- 分析PRISm的纵向轨迹和结果.
- 为了确定与PRISM进展相关的因素.
主要方法:
- 利用了PLATINO研究的数据,这是拉丁美洲的一项以人口为基础的调查.
- 包括2942名基线参与者和2026名随访者 (5-9年后).
- 定义的PRISm使用FEV1/FVC≥0.70与FEV1<80%预测后支气管扩张.
主要成果:
- PRISm的患病率为5.0% (95% CI 4.2-5.8),与较低的教育程度和COPD症状相关.
- 与正常螺旋计相比,PRISm (HR 1.97) 和COPD GOLD 1-4类别的死亡风险明显更高.
- PRISm经常过渡到其他类别 (46.5%),其中19.8%进展为COPD.
结论:
- PRISm是一个异质和不稳定的条件.
- PRISm与死亡率增加和COPD的进展有关.
- 对于患有PRISm的人来说,需要进行适当的后续检查.
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