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Cancer therapies are various modes of treatment, such as surgery, radiation therapy, and chemotherapy that are administered to cancer patients.
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Polymalic Acid-based Nano Biopolymers for Targeting of Multiple Tumor Markers: An Opportunity for Personalized Medicine?
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纳米酶用于瘤治疗:表面修饰问题

Guoheng Tang1,2, Jiuyang He1, Juewen Liu3

  • 1CAS Engineering Laboratory for Nanozyme, Key Laboratory of Protein and Peptide Pharmaceutical, Institute of Biophysics Chinese Academy of Sciences Beijing 100101 P. R. China.

Exploration (Beijing, China)
|June 27, 2023
PubMed
概括

氧化铁纳米酶的表面修饰对于有效的瘤催化疗法至关重要. 定制它们的表面特性可以增强反应性氧物种的产生,并改善对抗癌症的治疗结果.

关键词:
在Fe3O4纳米酶中.细胞毒性 细胞毒性具有类似过氧酶的活性.表面的修改表面的修改瘤催化疗法是一种催化疗法.

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科学领域:

  • 生物医学工程 生物医学工程
  • 纳米技术纳米技术
  • 催化剂是一种催化剂.

背景情况:

  • 纳米酶在生物医学应用中比天然酶具有优势,包括增强的稳定性和易于生产.
  • 纳米酶的过氧酶类活性是通过活性氧物种 (ROS) 生成瘤催化疗法的关键.
  • 氧化铁 (Fe3O4) 纳米酶,早期的例子具有类似过氧化酶的活动,显示出瘤治疗的希望,但产生不一致的结果.

研究的目的:

  • 审查Fe3O4纳米酶在瘤治疗中的催化机制.
  • 讨论表面修饰对Fe3O4纳米酶性能的影响.
  • 为改善基于纳米酶的抗瘤活性提供前景.

主要方法:

  • 在瘤催化疗法中Fe3O4纳米酶的文献综述.
  • 对影响纳米酶过氧化酶类活性的因素的分析.
  • 评估表面修饰对生物分布和细胞内命运的影响.

主要成果:

  • 与Fe3O4纳米酶观察到不一致的细胞毒性和ROS清除.
  • 表面修饰显著影响Fe3O4纳米酶过氧化酶活性.
  • 表面特性影响纳米酶生物分布和细胞相互作用,影响治疗疗效.

结论:

  • 表面修饰对于优化Fe3O4纳米酶在癌症中的治疗效果至关重要.
  • 了解表面结构活动关系对于纳米酶设计至关重要.
  • 有针对性的表面工程可以增强基于纳米酶的瘤催化疗法.