较弱的最大关节和较弱的小关节与正常的最大关节:两种互补的新征兆来诊断下肢功能衰弱
Masahiro Sonoo1, Takamichi Kanbayashi1, Shunsuke Kobayashi1
1Department of Neurology, Teikyo University School of Medicine, Tokyo, Japan.
Brain and behavior
|June 27, 2023
概括
新的神经症状可以帮助诊断下肢的功能衰弱. "较弱的关节最大"标志显示出高灵敏度,而"较弱的阴与正常的关节最大"在区分功能性弱点和结构性弱点方面具有高度特异性.
科学领域:
- 神经学 神经学
- 神经科学是一个神经科学.
- 医学诊断 医学诊断 医学诊断
背景情况:
- 功能神经障碍的诊断依赖于临床症状.
- 从临床上看,区分功能性弱点和结构性弱点是非常重要的.
- 需要用于下肢疲软的新型诊断标志.
研究的目的:
- 引入和验证两种新的互补的神经学标志,用于诊断下肢功能缺陷.
- 为了评估"较弱的最大关节"和"较弱的阴与正常的最大关节"标志的诊断实用性.
主要方法:
- 具有功能衰弱 (FW) 或结构衰弱 (SW) 的患者的回顾性招募.
- 使用医学研究理事会 (MRC) 关于关节最大肌肉 (GM) 和斜肌肉在卧卧姿势中的强度的检查.
- 定义"弱GM"为MRC得分≤4和"弱 iliopsoas与正常GM"为 iliopsoasMRC得分≤4与GMMRC得分=5.
主要成果:
- 该研究包括31名FW患者和72名SW患者.
- "弱转基因"标志显示了100%的灵敏度和85%的特异性.
- "有正常基因变异的弱小"标志是100%针对SW的特异性.
结论:
- 新描述的神经症状在区分下肢功能性弱点和结构性弱点方面表现有前途.
- 这些迹象可能有助于临床医生在一般神经病学环境中.
- 拟议的"弱转基因"和"弱转基因和正常转基因的阴茎"标志需要进一步调查临床效用.
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