在社区获得性肺炎患者中识别耐药性病原体
Francesco Amati1,2, Francesco Bindo2,3, Anna Stainer1,2
1Department of Biomedical Sciences, Humanitas University, Via Rita Levi Montalcini 4, Pieve Emanuele, 20072 Milan, Italy.
广谱抗生素越来越多地用于社区获得性肺炎 (CAP),因为人们担心抗药性病原体 (DRP). 然而,它们的过度使用可能会导致不良事件和成本增加,需要对识别方法和结果进行审查.
科学领域:
- 传染性疾病 传染性疾病
- 临床药房 临床药房
- 流行病学 流行病学
背景情况:
- 15年来,社区获得性肺炎 (CAP) 的广泛抗生素使用增加.
- 在CAP患者中,耐药病原体 (DRP) 如MRSA和Pseudomonas aeruginosa的发病率上升.
- 根据当地生态,医疗保健系统和国家,DRP发病率的变化.
研究的目的:
- 分析 CAP 中识别 DRP 的方法.
- 评估与CAP中广泛抗生素使用相关的结果.
- 评估与CAP广泛抗生素治疗相关的不良事件.
主要方法:
- 对CAP中DRP识别的已发表研究的审查.
- 对DRP发病率的流行病学数据的分析.
- 审查关于广泛抗生素治疗结果和不良事件的研究.
主要成果:
- 有证据表明,DRP在CAP中的发病率因地区而异.
- 过度使用广谱抗生素与成本增加,住院,不良事件和耐药性有关.
- 广谱抗生素在改善农业政策成果方面的有效性受到质疑.
结论:
- 目前在CAP中识别DRP的方法需要仔细考虑当地流行病学.
- 谨慎使用广谱抗生素对于减轻耐药性,不良事件和医疗保健成本的风险至关重要.
- 需要进行进一步的研究,以优化CAP管理中的抗生素策略.
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