临床和剂量参数与前列腺支架治疗后尿道毒性的关联:长期单一机构经验
Masaya Ito1,2, Chiyoko Makita2, Takayuki Mori2
1Department of Radiation Oncology, Gifu Takayama Red Cross Hospital, 3-11, Tenmancho, Takayama City 500-8717, Gifu, Japan.
Current oncology (Toronto, Ont.)
|June 27, 2023
概括
较高的基线尿症状得分预测前列腺癌低剂量率支臂治疗后的长期问题. 患者的选择是减少晚期尿道毒性的关键.
科学领域:
- 在瘤学瘤学.
- 泌尿器科 泌尿器科 泌尿器科 泌尿器科
- 辐射疗法 辐射疗法
背景情况:
- 前列腺癌的治疗通常涉及放射治疗.
- 低剂量率支臂治疗 (LDR-BT) 是前列腺癌的常见治疗方法.
- 在LDR-BT之后,尿道毒性是一个重大问题.
研究的目的:
- 调查前列腺癌LDR-BT后临床,治疗和剂量参数与晚期尿道毒性之间的关联.
- 为了确定LDR-BT后长期下尿道症状 (LUTS) 和过度活跃的膀 (OAB) 的预测因素.
主要方法:
- 对203名用LDR-BT治疗的前列腺癌患者 (2007-2016) 的回顾性研究.
- 通过使用国际前列腺症状评分 (IPSS) 和过度活性膀症状评分 (OABSS) 评估尿道毒性.
- 对不同时间点与LUTS和OAB相关的临床,治疗和剂量测量因素的分析.
主要成果:
- IPSS和OABSS得分在治疗后暂时恶化,但在大多数患者中在18-36个月内恢复到基线水平.
- 较高的基线IPSS和OABSS与24个月和60个月中度/重度LUTS和OAB的增加相关.
- 在24个月和60个月的LUTS/OAB和LDR-BT剂量计因子之间没有发现相关性.
结论:
- 虽然长期尿道毒性率较低,但基线尿道症状严重程度是长期功能的一个重要预测指标.
- 根据基线泌尿症状改进患者选择,可能进一步降低LDR-BT后的长期泌尿毒性.
- 在这个队列中,LDR-BT的剂量因子没有预测晚期尿道毒性.
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