血清和下降路径在休息状态下和对慢性鞭相关疾病患者运动反应中的基于绩效的认知功能上的作用:一项随机控制交叉研究
Iris Coppieters1,2,3, Jo Nijs1,2,4,5, Mira Meeus3,6
1Pain in Motion Research Group (PAIN), Department of Physiotherapy, Human Physiology and Anatomy, Faculty of Physical Education and Physiotherapy, Vrije Universiteit Brussel, 1090 Brussels, Belgium.
Clinics and practice
|June 27, 2023
概括
选择性上腺素再吸收抑制剂 (Atomoxetine) 改善了慢性鞭相关疾病 (CWAD) 患者的选择性注意力. 然而,阿托莫克西丁和选择性血清素再吸收抑制剂 (Citalopram) 都在运动期间恶化了认知表现.
科学领域:
- 神经科学是一个神经科学.
- 认知心理学 认知心理学
- 药理学 药理学是指药理学的学科.
背景情况:
- 血清和腺系统的调节失调与慢性鞭相关疾病 (CWAD) 的认知障碍有关.
- 涉及这些神经递质的下降途径可能会影响CWAD患者的认知功能.
研究的目的:
- 为了研究下降的血清和诺亚上腺体通路在认知功能中的作用.
- 评估选择性血清素再吸收抑制剂 (SSRI) 和选择性上腺素再吸收抑制剂 (SNRIs) 对休息状态和运动期间CWAD认知的影响.
主要方法:
- 这是一项双盲,随机,受控的交叉研究,涉及25名CWAD患者.
- 调节下降抑制机制使用单剂量Citalopram (SSRI) 或Atomoxetine (SNRI).
- 在三个条件下评估休息和运动后的认知表现:没有药物,Citalopram和Atomoxetine.
主要成果:
- 与没有药物的情况相比,阿托莫克赛丁显著改善了选择性注意力 (p < 0.05).
- 西塔洛普拉姆并没有显著影响休息时的认知功能.
- 选择性注意力仅在没有药物的情况下与运动改善;Citalopram和Atomoxetine在运动后注意力受损.
结论:
- 在CWAD患者中,单剂量阿托莫克赛丁在选择性注意力方面表现出适度的改善,而在静止状态下,奇塔洛普拉姆没有影响.
- 在CWAD患者中,运动仅在没有药物治疗的情况下改善了选择性注意力.
- 在这个人群中,SSRI和SNRI都在亚最大有氧运动期间对认知表现产生了负面影响.
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