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在体外生物污染性能-合金钻石微电极用于色素检测使用快速扫描周期电压测量

Bhavna Gupta¹, Mason L Perillo², James R Siegenthaler^3,4

¹Neuroscience Program, Michigan State University, East Lansing, MI 48824, USA.

|June 27, 2023

概括

用添加的钻石微电极 (BDDMEs) 提供了更好的稳定性和减少生物污染,用于检测神经精神疾病中的关键神经递质 - - 血清醇. 这些钻石电极对慢性体内生物传感应用有很大的前景.

科学领域:

神经科学是一个神经科学.
电化学电化学电化学
材料科学材料科学材料科学

背景情况:

神经递质释放对于理解神经疾病至关重要.
血清激素在神经精神疾病中起着重要作用.
碳纤维微电极 (CFMEs) 用于血清激素检测,但患有慢性稳定性差和生物污染.

研究的目的:

为了比较新型添加钻石微电极 (BDDME) 与传统CFME的电化学行为.
评估BDDME在不同条件下检测血清素 (5-HT) 的性能.
评估BDDME作为长期植入生物传感器的潜力.

主要方法:

在体外电化学测量血清素 (5-HT).
快速扫描循环电压测量 (FSCV) 具有不同的波形参数.
评估生物污染对电极性能的影响.
在BDDME和CFME之间进行比较.

主要成果:

与CFMEs相比,BDDMEs对FSCV参数的变化和更高度表现出更持续的血清素反应.
生物污染导致BDDME的电流减少不那么显著,特别是"杰克逊"波形.
CFME 提供了较低的血清的检测极限.

结论:

与CFMEs相比,BDDMEs表现出较强的稳定性和生物污染抵抗力,用于色胺检测.
BDDME显示出开发成慢性植入生物传感器的显著潜力,用于体内神经递质监测.
对于高级神经科学应用,BDDME的进一步优化是有必要的.

关键词:

生物污染是一种生物污染.用添加的钻石.碳纤维是一种碳纤维.快速扫描周期电压测量微电极是一种微电极.神经递质检测神经递质检测血清胺 (serotonin) 是一种神经元.

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