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基于聚合物的分子打印电化学传感器用于诊断传染病

Greta Pilvenyte^1,2, Vilma Ratautaite^1,2, Raimonda Boguzaite^1,2

¹Department of Nanotechnology, State Research Institute Center for Physical Sciences and Technology (FTMC), Saulėtekio Av. 3, LT-10257 Vilnius, Lithuania.

|June 27, 2023

概括

分子印记聚合物 (MIP) 生物传感器为快速,病原体特异性检测传染病生物标志物提供了有前途的方法. 这些电化学传感器显示出改善诊断和打击抗菌素耐药性的潜力.

科学领域:

生物医学工程生物医学工程
分析化学分析化学
传染病诊断传染病诊断传染病诊断

背景情况:

体液中的生物标志物有助于疾病检测,但由于病原体的识别速度缓慢,目前的诊断往往导致经验性抗微生物治疗.
快速,具体和用户友好的测试对于有效的医疗保健和打击抗菌素耐药性至关重要.

研究的目的:

审查用分子印记聚合物 (MIP) 修改的电化学传感器的最新进展.
专注于检测基于蛋白质的生物标志物用于感染性疾病,如HIV-1,COVID-19和登革热病毒.
分析基于MIP的电化学传感器的开发,材料和性能.

主要方法:

对基于MIP的电化学传感器用于生物标志物检测的最新文献的综述.
分析用于传感器开发的各种电极应用和聚合物材料.
已建立的检测极限和研究方法的比较.

主要成果:

基于MIP的电化学传感器显示出检测特定传染病生物标志物的巨大潜力.
材料的选择和电极的修改会影响传感器性能和检测极限.
该审查涵盖了生物标志物的传感器,包括C反应蛋白 (CRP) 和SARS-CoV-2尖端糖蛋白.

结论:

基于MIP的电化学传感器是一种可行的技术,用于快速和具体检测传染病生物标志物.
在材料和传感器设计的进一步发展可以提高诊断能力.
这些传感器有望改善患者的治疗结果和控制抗菌素耐药性.

关键词:

电化学传感器是一种电化学传感器.传染病生物标志物传染病生物标志物分子印记聚合物 (MIP) 是一种分子印记聚合物.

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