分子定义的细胞癌的临床特征
Xinfeng Hu1, Congzhu Tan1, Guodong Zhu1
1Department of Urology, The First Affiliated Hospital of Xi'an Jiaotong University, Xi'an 710061, China.
Current issues in molecular biology
|June 27, 2023
概括
基于分子类型的新瘤分类正在出现,但缺乏研究和诊断标准. 本综述总结了关于分子定义细胞癌 (RCC) 检测和治疗的当前知识.
科学领域:
- 在瘤学瘤学.
- 病理学 病理学 病理学
- 遗传学 是一个遗传学.
背景情况:
- 脏瘤代表着多样化的组织病理实体,每年有超过040万个新病例,主要是中年到老年男性.
- 2022年世界卫生组织 (WHO) 的分类引入了新的细胞癌 (RCC) 类别,基于分子类型.
- 目前对这些分子定义的RCC类型的研究是有限的,缺乏精确的诊断标准,可能导致不理想的治疗结果.
研究的目的:
- 对过去15年的文献进行叙事审查,重点关注分子定义的RCC.
- 整合关于分子定义RCC的临床特征的信息.
- 总结关于分子定义RCC的检测和治疗的当前研究状况.
主要方法:
- 对过去15年的文献进行了全面的搜索.
- 审查的重点是详细介绍分子定义细胞癌 (RCC) 的研究.
- 综合信息涵盖了临床特征,检测方法和治疗策略.
主要成果:
- 2022年世界卫生组织分类将RCC分类扩展到新的分子定义亚型.
- 许多新型RCC亚型缺乏确立的临床诊断标准.
- 治疗方案通常与透明细胞RCC (ccRCC) 的治疗方案相似,可能会影响其他亚型的疗效.
结论:
- 分子定义的RCC亚型需要进一步调查以确定准确的诊断标准.
- 针对分子定义的RCC需要量身定制的治疗策略,以改善患者的治疗结果.
- 对分子定义的RCC的持续研究对于推进个性化瘤学的发展至关重要.
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