不同的大脑疾病和多病症对妄叠加痴呆症 (DSD) 的贡献
Tilman Wetterling1, Klaus Junghanns2
1Department of Psychiatry, Vivantes Klinikum Kaulsdorf, 12621 Berlin, Germany.
Geriatrics (Basel, Switzerland)
|June 27, 2023
概括
痴呆症叠加 Delirium (DSD) 是常见的,但触发因素尚不清楚. 这项研究发现,多发症和脑部变化都不能预测DSD,这表明年龄和痴呆阶段是关键因素.
科学领域:
- 神经科学是一个神经科学.
- 老年病的医生 老年病的医生
- 精神病学是一个精神病学.
背景情况:
- 痴呆症叠加 Delirium (DSD) 是一种急性神经精神疾病,常见于患有渐进性认知衰退的患者.
- 了解DSD的触发因素和易感因素是非常重要的,因为它的高频率和临床意义.
- 关于潜在的大脑疾病和多病症对DSD发展的具体影响的现有知识仍然有限.
研究的目的:
- 调查潜在的大脑病理和多病症 (MM) 对痴呆症 (DSD) 叠加 Delirium 的发生的影响.
- 通过比较患有DSD的患者群体,单独的痴呆症,单独的妄想症和其他精神疾病来确定DSD的潜在诱导因素.
主要方法:
- 使用GePsy-B数据库来获取患者数据.
- 使用累积疾病评分表 (CIRS) 和ICD-10诊断来评估多病症.
- 使用临床痴呆症评分 (CDR) 尺度诊断的痴呆症和使用DSM-IV-TR标准的妄想症.
- 根据CT扫描结果对DSD病例进行分类:大脑缩,脑梗塞或白质超强度 (WMH).
主要成果:
- 在DSD组和对照组之间没有观察到CIRS分数的显著差异.
- 根据CT发现 (脑缩,心脏病发作,WMH) 分类的DSD患者组,多病症指数没有显著差异.
- 回归分析发现,只有年龄和痴呆阶段是DSD的重要影响因素.
结论:
- 这项研究表明,通过CIRS和ICD-10诊断测量的多病症并不是DDS的诱导因素.
- 大脑的形态变化,包括大脑缩,心脏病发作和WMH,似乎不会使个人易患DSD.
- 年龄和痴呆的阶段是与痴呆症叠加的痴呆症发展相关的主要确定因素.
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