基于乳的果糖的配方和表征:关于营养药物输送的初步研究
Somali Dhal1, Anupam Pal2, Anna Gramza-Michalowska3
1Department of Biotechnology and Medical Engineering, National Institute of Technology Rourkela, Rourkela 769008, India.
Gels (Basel, Switzerland)
|June 27, 2023
概括
消费者友好的营养药物是使用含有结构化乳液的基糖果制成的. 这些新型乳化剂成功地提供了可溶于油的黄素和可溶于水的 рибофлавин,为新的口服剂型铺平了道路.
科学领域:
- 食品科学与技术 食品科学与技术
- 制药科学 制药科学
- 材料科学 材料科学 材料科学
背景情况:
- 消费者对营养保健品的接受往往受到不方便的剂量形式的限制.
- 开发用户友好的输送系统对于提高营养药的生物可用性和有效性至关重要.
- 结构化乳液 (乳液) 为封装各种活性成分提供了一个有前途的平台.
研究的目的:
- 开发消费者友好的,基于乳的糖果糖果剂量形式,用于营养药物输送.
- 将油溶性 (黄素) 和水溶性 (黄素) 营养药物合并到单一剂型中.
- 研究含有橄油的基于点丁的乳化剂的物理化学特性和稳定性.
主要方法:
- 制备含有不同度的橄油 (10-30%) 作为结构化乳液的基糖果糖果.
- 使用富里埃变换红外光谱 (FTIR) 和差分扫描热度计 (DSC) 进行乳化剂的表征.
- 实验室分解研究和评估双重营养药物 (黄素和 рибофлавин) 传递能力.
主要成果:
- 橄油的纳入影响了点网的形成和糖结晶,这是FTIR和DSC证实的.
- 基于乳的糖果表现出一致的分解概况,尽管橄油度不同.
- 开发的果糖配方有效地提供了水友和疏水性营养药剂.
结论:
- 果糖形式的基于pectin的乳膜是可行的剂量形式,用于同时提供水友性和水害性营养品.
- 这种方法为口服营养药物输送提供了一种新的,消费者友好的战略.
- 对这些双模式载体的进一步研究可以导致创新的营养药产品开发.
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