概念化和研究多元组件聚合物网络作为潜在的皮质类固醇载体
Dilyana Georgieva1, Mariela Alexandrova2, Sijka Ivanova2
1Department of Pharmaceutical Technology and Biopharmacy, Faculty of Pharmacy, Medical University of Sofia, Dunav Str. 2, 1000 Sofia, Bulgaria.
Gels (Basel, Switzerland)
|June 27, 2023
概括
新的聚合物网络提供了一个有前途的平台,可以通过皮肤传递甲酸 (DSP),最大限度地减少系统性副作用. 这些材料显示了可控的药物加载和释放,用于有效的局部应用.
科学领域:
- 聚合物化学 聚合物化学
- 材料科学 材料科学 材料科学
- 皮肤病学 皮肤病学
背景情况:
- 德克萨米他 (DXM) 是一种具有强效抗炎功能的葡萄糖皮质类药物.
- 系统性DXM的使用会产生不良影响,需要使用替代的输送方法.
- 德克萨米他酸 (DSP) 的皮肤应用需要有效的药物输送平台.
研究的目的:
- 开发和描述多元组件聚合物网络,用于通过皮肤输送德克萨米酸 (DSP).
- 评估这些新型聚合物网络的药物加载和体外释放能力.
主要方法:
- 合成共聚合物网络 (CPN) 和相互透的聚合物网络 (IPN) 使用氧化还原聚合和交联.
- 通过FTIR,TGA和各种溶剂和DSP溶液中的胀动力学研究进行表征.
- 在37°C的缓冲溶液 (pH 7.4) 中进行体外药物释放研究.
主要成果:
- 在24小时内,CPN和IPN在水性介质中表现出高胀度 (高达1800%和1200%).
- IPN表现出对温度反应的胀,在更高的温度下胀减少.
- 药物加载能力可以通过DSP溶液度来控制.
- 观察到DSP在体外成功释放,证实了平台的可行性.
结论:
- 开发的多元组件水友性聚合物网络是DSP潜在皮肤应用的有效平台.
- 这些网络提供了适合局部治疗的可控药物加载和释放配置文件.
- 该研究强调了一种有前途的策略,旨在提高治疗疗效,同时减轻德克萨米他的全身副作用.
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