林科米辛 HCl 载荷的 醇基 现场凝 治疗牙周炎
Napaphol Puyathorn1, Nutdanai Lertsuphotvanit2, Takron Chantadee3,4
1Programme of Pharmaceutical Engineering, Department of Industrial Pharmacy, Faculty of Pharmacy, Silpakorn University, Nakhon Pathom 73000, Thailand.
Gels (Basel, Switzerland)
|June 27, 2023
概括
新的在位形成凝 (ISG) 装载着林氏素化物提供持续的牙周药物递送. 这些基于玻利的ISG显示出对关键牙周炎病原体有前途的抗菌活性.
科学领域:
- 制药科学 制药科学
- 生物材料科学 生物材料科学
- 药物输送系统 药物输送系统
背景情况:
- 溶剂交换诱导的 in situ 形成凝 (ISG) 对于局部药物递送是有效的,特别是在牙周口袋中.
- 林氏素化物是牙周炎的潜在治疗剂.
研究的目的:
- 开发和描述使用玻利基因矩阵用于牙周应用的用林科米辛化物加载的ISG.
- 评估开发的ISG的物理化学特性,药物释放动力学和抗菌疗效.
主要方法:
- 使用40%的玻利基质和N-甲基利 (NMP) 作为溶剂制备ISG.
- 评估ISG粘度,表面张力,凝性质和耐水性.
- 对林氏素HCl释放动力学和抗菌活性对相关口腔病原体 (黄金葡萄球菌,大肠杆菌, Porphyromonas gingivalis,Candida albicans) 的评估.
主要成果:
- 准备好的ISG表现出有利的低粘度和扩散性,凝形成受到药物加载和溶剂交换的影响.
- 含林氏素HCl的ISG在8天内持续释放药物,遵循Fickian扩散动力学 (Higuchi模型).
- ISG显示了关键牙周炎细菌的剂量依赖抑制和有效的抑制 Candida albicans由释放的NMP.
结论:
- 含林氏素HCl的玻利基ISGs是一种有前途的局部药物输送系统,用于牙周炎.
- 该配方表现出持续释放和强大的抗菌活性,支持其治疗牙周感染的潜力.
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