蛋白和凝的合物为基于凝的组织工程的平台
Karinna Georgiana Pele1, Hippolyte Amaveda2, Mario Mora2
1Multiscale in Mechanical & Biological Engineering Research Group, Aragon Institute of Engineering Research (I3A), School of Engineering & Architecture, University of Zaragoza, 50018 Zaragoza, Aragon, Spain.
Gels (Basel, Switzerland)
|June 27, 2023
概括
蛋白和凝合物对组织工程有很大的前景. 这些新型生物材料支持细胞生长,可以制造成用于再生医学应用的支架.
科学领域:
- 生物材料科学 生物材料科学
- 组织工程是组织工程.
- 再生医学是一种再生医学.
背景情况:
- 创新材料对于组织工程和再生医学 (TERM) 是至关重要的.
- 自然来源的材料是首选的,因为它们的成本低,可用性和生物活性.
- 蛋白 (EW) 是一个未充分利用的蛋白质来源,其与凝的类化合物尚未被用于TERM.
研究的目的:
- 为了研究蛋白 (EW) 和凝的混合类化合物,作为基于水凝的组织工程的平台.
- 探索它们在2D涂层膜,3D水凝在微流体设备中的应用,以及3D水凝支架中的应用.
- 描述这些新化合物的物理,机械和生物特性.
主要方法:
- 风湿学评估,以确定温度和EW度对合物粘度的影响.
- 制造2D合物薄膜和3D水凝支架.
- 在体外细胞培养研究以评估细胞生长和透.
- 水凝地形的特征,机械性能和水的亲和力.
主要成果:
- 病理学证实,温度和EW度可以调整合物凝粘度.
- 与单独使用EW相比,2D电影展示了球状纳米拓,混合合物增强了细胞生长.
- 在微流体器件中,合物成功地形成了用于细胞研究的3D水凝环境.
- 制造的3D支架具有毛孔,叶片,球状纳米拓,可调节的机械性能,并支持细胞增殖和透.
结论:
- 混合的EW和凝的合物为各种TERM应用提供了一个多功能平台.
- 这些材料显示出创造组织模型,有机体和可植入器件的潜力.
- 它们的可调节性质和生物相容性使它们适合生物打印和再生医学策略.
相关概念视频
01:13Protein Organization
Overview
01:13Protein Organization
Overview
01:56Structural Protein Function
Structural proteins are a category of proteins responsible for functions ranging from cell shape and movement to providing support to major structures such as bones, cartilage, hair, and muscles. This group includes proteins such as collagen, actin, myosin, and keratin.
Collagen, the most abundant protein in mammals, is found throughout the body. In connective tissue, such as skin, ligaments, and tendons, it provides tensile strength and elasticity. In bones and teeth, it mineralizes to form...
Collagen, the most abundant protein in mammals, is found throughout the body. In connective tissue, such as skin, ligaments, and tendons, it provides tensile strength and elasticity. In bones and teeth, it mineralizes to form...
01:24Protein Organization
Proteins are polymers of amino acid residues. They are versatile and responsible for different cellular functions, including DNA replication, molecular transport, catalysis, and structural support. Proteins have a hierarchical structure comprising at least three levels of organization: primary, secondary, and tertiary structure. Some large proteins have a quaternary structure where individual protein subunits are linked together.
The primary structure of a protein is its amino acid sequence.
The primary structure of a protein is its amino acid sequence.
01:56Structural Protein Function
Structural proteins are a category of proteins responsible for functions ranging from cell shape and movement to providing support to major structures such as bones, cartilage, hair, and muscles. This group includes proteins such as collagen, actin, myosin, and keratin.
Collagen, the most abundant protein in mammals, is found throughout the body. In connective tissue, such as skin, ligaments, and tendons, it provides tensile strength and elasticity. In bones and teeth, it mineralizes to form...
Collagen, the most abundant protein in mammals, is found throughout the body. In connective tissue, such as skin, ligaments, and tendons, it provides tensile strength and elasticity. In bones and teeth, it mineralizes to form...
01:24Protein Organization
Proteins are polymers of amino acid residues. They are versatile and responsible for different cellular functions, including DNA replication, molecular transport, catalysis, and structural support. Proteins have a hierarchical structure comprising at least three levels of organization: primary, secondary, and tertiary structure. Some large proteins have a quaternary structure where individual protein subunits are linked together.
The primary structure of a protein is its amino acid sequence.
The primary structure of a protein is its amino acid sequence.