威胁网络:用于生物威胁检测和预警的超基因组监控网络
Siddhanth Sharma1, Jaspreet Pannu2, Sam Chorlton3
1Siddhanth Sharma, MD MPH, is a Public Health Registrar, Metropolitan Communicable Disease Control, Perth, Australia.
Health security
|June 27, 2023
概括
使用临床元基因组下一代测序 (mNGS) 早期发现病原体可以减轻大流行. 一个拟议的网络,即威胁网,可以高概率地检测出像SARS-CoV-2这样的新型呼吸道病毒,防止广泛爆发.
科学领域:
- 传染病流行病学传染病流行病学
- 基因组监测是指基因组的监测.
- 公共卫生准备 公共卫生准备
背景情况:
- 早期发现新型病原体对于预防流行病至关重要.
- 下一代元基因组测序 (mNGS) 为快速发现病原体提供了一个潜在的工具.
- 医院急诊室是识别新出现的传染病的关键点.
研究的目的:
- 提出和评估一种称为"威胁网"的临床元基因组下一代测序 (mNGS) 架构,用于早期检测新型呼吸道病原体.
- 为了估计威胁网络在美国的成本和流行病学有效性.
- 量化常规临床mNGS在流行病准备中的价值.
主要方法:
- 开发一个易感暴露感染移除 (SEIR) 模拟模型.
- 分析威胁网络在不同医院覆盖层面的有效性.
- 对类似SARS-CoV-2病原体的检测概率,成本和流行病学影响的估计.
主要成果:
- 威胁网可以在医院中部署,覆盖30%的美国人口.
- 据估计,每年的成本在4亿至8亿美元之间.
- 在全国范围内经过10次ED呈现和79次感染后,检测SARS-CoV-2类病原体的概率为95%.
结论:
- 实施威胁网可以显著提高呼吸系统流行病威胁的早期检测.
- 常规的临床mNGS监测提供了一个有价值的策略,以减轻大流行.
- 这种方法可以帮助预防或大幅减少新型传染病原体的传播.
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