瞳孔大小反映了在休息期间皮下上升激发系统核的激活
Beth Lloyd1, Lycia D de Voogd2,3, Verónica Mäki-Marttunen1
1Institute of Psychology, Leiden University, Leiden, Netherlands.
eLife
|June 27, 2023
概括
在休息期间自发的瞳孔尺寸变化与上升唤醒系统 (AAS) 的活动密切相似. 这一发现表明,即使没有外部刺激,瞳孔直径也可以作为AAS核功能的非侵入性标志物.
科学领域:
- 神经科学是一个神经科学.
- 认知神经科学 认知神经科学
- 心理生理学 心理生理学
背景情况:
- 上升兴奋系统 (AAS) 中的神经调节核调节大脑状态和表现.
- 瞳孔直径是AAS活动的潜在非侵入性指标,特别是在任务期间.
- 瞳孔大小和休息期间AAS活动之间的关系尚不清楚.
研究的目的:
- 为了研究瞳孔直径自发变化和静止状态期间关键AAS核中的活性之间的合.
- 确定瞳孔大小是否可以作为休息期间AAS功能的可靠,非侵入性生物标志物.
主要方法:
- 同时从74名参与者获得休息状态功能磁共振成像 (fMRI) 和瞳孔大小记录.
- 分析的重点是六个核心AAS核:位置coeruleus,腹部 tegmental区域,黑色物质,背部拉菲,中间拉菲,和胆基底前脑.
- 在AAS核中,瞳孔尺寸波动和BOLD信号变化之间的相关性在各种时间延迟下被检查.
主要成果:
- 所有六个研究的AAS核中的活性都显示出在0-2秒的滞后时间内与瞳孔大小的最佳相关性.
- 瞳孔尺寸的自发变化很快就被AAS核中相应的BOLD信号变化所追随.
- 在休息期间瞳孔-AAS合的时间动态与在任务相关研究中观察到的更慢的血液动力学反应有显著差异.
结论:
- 休息期间自发的瞳孔尺寸变化是多个上升激发系统核中的活动的敏感指标.
- 瞳孔直径提供了一种有前途的非侵入性方法,用于评估静止状态下的AAS功能.
- 休息期间明显的合模式凸显了AAS调制的动态性质及其与自主措施的关系.
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