血型A增强了SARS-CoV-2感染的可能性
Shang-Chuen Wu1, Connie M Arthur1, Hau-Ming Jan1
1Department of Pathology, Joint Program in Transfusion Medicine, Brigham and Women's Hospital, Harvard Medical School, Boston, MA.
Blood
|June 27, 2023
概括
严重急性呼吸道综合征冠状病毒2 (SARS-CoV-2) 首选感染血液组A细胞. 这是因为SARS-CoV-2受体结合域特别结合血液组A抗原.
科学领域:
- 病毒学 病毒学
- 免疫学 免疫学 免疫学
- 葡萄糖生物学 葡萄糖生物学
背景情况:
- ABO (H) 血型抗原是严重急性呼吸系统综合征冠状病毒2 (SARS-CoV-2) 感染的已知的危险因素.
- 将ABO (H) 抗原与COVID-19易感性联系在一起的机制尚未完全理解.
- SARS-CoV-2受体结合域 (RBD) 与碳水化合物结合蛋白 galectins 有相似之处.
研究的目的:
- 为了研究SARS-CoV-2 RBD.的糖结合特异性.
- 为了比较SARS-CoV-2的RBD结合与 galectins的结合.
- 阐明ABO (H) 血型抗原在SARS-CoV-2感染中的作用.
主要方法:
- 利用甘氨酸阵列分析来比较SARS-CoV-2 RBD和加勒的结合概况.
- 评估了SARS-CoV-2变种 (包括Delta和Omicron) 对血液组A表达细胞的传染性.
- 研究了 galectins 对血型A细胞的SARS-CoV-2 感染的抑制作用.
主要成果:
- 包括Delta和Omicron变种在内的SARS-CoV-2 RBD对A型血液具有特异性.
- SARS-CoV-2病毒表现出感染血液组A表达细胞的优先能力.
- 一种结合血型的加勒胺抑制了SARS-CoV-2感染在A血型细胞中的增强,而非结合性加勒胺没有.
结论:
- SARS-CoV-2 直接与血液组A抗原发生接触.
- 这种结合提供了ABO (H) 血型表达和SARS-CoV-2感染易感性之间的直接机械联系.
- 这些发现提供了对COVID-19中宿主-病原体相互作用的见解.
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