由酸基水泥提取物诱导的ex vivo骨质生成
Gabriel Kato1,2, Rita Araújo1,2, Cláudia Rodrigues3
1Laboratory for Bone Metabolism and Regeneration, Faculty of Dental Medicine, University of Porto, 4200-393 Porto, Portugal.
Journal of functional biomaterials
|June 27, 2023
概括
像BiodentineTM和TotalFill® BC RRMTM Fast Putty这样的快速化的酸盐水泥比ProRoot® MTA更有效地提高了骨的发育. 这些水泥刺激组织矿化,而BiodentineTM在ex vivo骨模型中显示出最好的结果.
科学领域:
- 生物材料科学 生物材料科学
- 牙科材料 牙科材料
- 再生医学是一种再生医学.
背景情况:
- 基于酸的水泥 (CSCs) 在纸治疗中至关重要,促进组织矿化.
- 了解CSC对骨发育的生物学影响对于其临床应用至关重要.
研究的目的:
- 为了比较快速设置的CSC (BiodentineTM,TotalFill® BC RRMTM Fast Putty) 与缓慢设置的CSC (ProRoot® MTA) 的骨质生成潜力.
- 为了评估胚胎骨发育对CSC化物的ex vivo生物反应.
主要方法:
- 胚胎腿骨的器官类型培养,暴露于CSC化物10天.
- 评估骨质生成和骨形成使用微断层学和组织形态学.
主要成果:
- 所有的CSC化物都以剂量依赖的方式增加了骨质生成和组织矿化.
- 与ProRoot® MTA相比,快速设置的水泥 (BiodentineTM,TotalFill®) 显示出更高的性能.
- 在这个模型中,BiodentineTM对骨发育产生了最显著的积极影响.
结论:
- 与ProRoot® MTA相比,快速设置的CSC,特别是BiodentineTM,显示出增强的骨质生成特性.
- CSCs有效地刺激骨矿化,支持它们在再生性内牙科和骨缺陷治疗中的应用.
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