根据结果调整的加密球菌病的预防性治疗.
Fernando Messina1, Gabriela Santiso1, Alicia Arechavala1
1Mycology Unit, Infectious Diseases Hospital F.J. Muñiz, Buenos Aires C1282AEN, Argentina.
Journal of fungi (Basel, Switzerland)
|June 27, 2023
概括
在HIV患者中早期检测Cryptococcus抗原 (CrAg LFA) 和预防性治疗可以预防密码球菌脑膜炎. 这项研究表明,预防性治疗是有效的,即使在调整的可纳剂量.
科学领域:
- 传染性疾病 传染性疾病
- 菌类学 菌类学是指菌类学.
- 艾滋病毒 医学 艾滋病毒 医学
背景情况:
- 密码球菌病是一种严重的机会性感染在艾滋病毒感染者.
- 早期诊断和治疗对于管理加密菌病至关重要.
- 加密球菌抗原侧流检测 (CrAg LFA) 有助于早期检测.
研究的目的:
- 通过血清 CrAg LFA.诊断出密码球菌病的HIV患者的结局进行评估.
- 评估在没有神经系统参与的患者中预防性治疗的有效性.
- 分析适应诊断发现的治疗方案.
主要方法:
- 对70名艾滋病毒患者进行了回顾性,纵向性,分析性研究,通过血清CrAg LFA.诊断出患有密码球菌病的HIV患者.
- 分析2019年1月至2022年4月的医疗记录.
- 以血液培养,呼吸道样本和肺部成像为指导的治疗.
主要成果:
- 五十名患者接受了预防性治疗,没有微生物学或成像证据表明活跃的加密球菌病.
- 在接受预防性治疗的50名患者中,没有一个患上脑膜炎或脑膜炎复发.
- 在17名患者中诊断出肺部密码球菌病,在3名患者中诊断出真菌病.
结论:
- 预防性治疗有效地预防了CrAg LFA阳性患者脑膜炎的进展.
- 调整剂量的可纳预防疗法被证明是有益的,即使在较低的剂量.
- 早期的Crag LFA查和预防性管理对于与艾滋病毒相关的密码菌病至关重要.
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