流行病学,现代诊断和粘菌感染的管理
David Pham1, Annaleise R Howard-Jones2,3,4, Rebecca Sparks5
1Centre for Infectious Diseases & Microbiology, Westmead Hospital, Westmead, NSW 2170, Australia.
Journal of fungi (Basel, Switzerland)
|June 27, 2023
概括
一种致命的真菌感染 - - 粘菌菌,在全球范围内正在增加. 新的诊断和抗真菌药物对于更好的结果至关重要,特别是对于包括COVID-19患者在内的风险人群.
科学领域:
- 医学真菌学 医学真菌学
- 传染性疾病 传染性疾病
- 公共卫生 公共卫生
背景情况:
- 粘菌菌是一种严重的侵入性真菌感染,由Mucorales菌引起,被世界卫生组织指定为高优先病原体群.
- 与当前的抗真菌疗法相关的发病率增加和高死亡率突出显示,迫切需要改进管理策略.
- COVID-19已经成为一个重要的新风险因素,除了糖尿病和免疫损害等传统倾向之外.
研究的目的:
- 解决目前粘膜菌的诊断方法的局限性,这些诊断方法的灵敏度,特异性和可访问性都不够.
- 强调有必要进行强有力的流行病学监测,以了解疾病负担并识别有风险的人群.
- 突出新兴诊断和治疗策略在打击这种致命感染方面的潜力.
主要方法:
- 关于粘膜菌的流行病学,诊断和治疗现有文献的综述.
- 分析风险因素的影响,包括糖尿病,免疫损害和COVID-19.
- 评估新兴的诊断技术 (血清学,分子) 和抗真菌剂.
主要成果:
- 目前用于粘膜性菌根病的诊断工具缺乏足够的准确性和及时的可用性.
- COVID-19 是一个新发现的重要风险因素,有助于粘膜菌病的发病率.
- 新兴的诊断方法和新型抗真菌剂显示出希望,但需要进一步验证和公平获取.
结论:
- 迫切需要加强粘膜菌的流行病学监测.
- 诊断灵敏度,特异性和可访问性的进步对于及时启动治疗至关重要.
- 公平获得新型抗真菌疗法至关重要,以减少与粘真菌菌相关的高死亡率.
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