在威尔士获得对肺细胞瘤病的理解
Jonathan Ayling-Smith1,2, Matthijs Backx3, Elizabeth Grant1
1Cardiff and Vale University Health Board, University Hospital of Wales, Cardiff CF14 4XW, UK.
Journal of fungi (Basel, Switzerland)
|June 27, 2023
概括
肺囊性肺炎 (PcP) 在威尔士比以前认为的更为常见. 非艾滋病毒相关的免疫抑制导致PcP死亡率显著上升,强调需要提高认识和及时诊断.
科学领域:
- 医学真菌学 医学真菌学
- 传染性疾病 传染性疾病
- 公共卫生流行病学 流行病学
背景情况:
- 肺囊性肺炎 (PcP) 是一种严重的机会性感染,特别是在免疫功能低下的人群中.
- 之前在威尔士的发病率估计主要集中在艾滋病毒和移植接受者.
- 需要在各种免疫抑制原因中准确的发病率数据和死亡率影响.
研究的目的:
- 用实验室数据确定威尔士PcP的发病率.
- 分析不同免疫抑制原因对PcP患者死亡率的影响.
- 为了将PcP发病率与之前的估计进行比较.
主要方法:
- 从2015年至2018年对阳性肺囊PCR结果的回顾性分析.
- 包括已证实临床和放射性PcP相关性的患者.
- 审查医疗记录,以评估免疫抑制原因和死亡结果.
主要成果:
- 在2015年至2018年期间,确定了159个独特的PCP病例 (平均每年39.75例).
- 计算出威尔士每10万人口中有1.23-1.26例的发病率.
- 在非艾滋病毒免疫抑制患者 (59%) 和艾滋病毒患者 (12%) 相比,观察到显著更高的一年死亡率.
结论:
- 威尔士的PcP发病率高于此前的估计,特别是在非HIV免疫受损群体中.
- 与非艾滋病毒相关的免疫抑制与PcP死亡率大幅增加有关.
- 在非艾滋病毒风险人群中提高对PcP的临床认识对于及时诊断和改善生存结果至关重要.
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