在重症监护室的COVID-19相关的肺阿斯伯吉洛症来自波兰的患者
Magdalena Skóra1, Mateusz Gajda1, Magdalena Namysł2
1Chair of Microbiology, Faculty of Medicine, Jagiellonian University Medical College, Czysta 18 Street, 31-121 Krakow, Poland.
Journal of fungi (Basel, Switzerland)
|June 27, 2023
概括
这项研究发现,在波兰的重症监护病房 (ICU) 中,COVID-19相关的肺阿斯伯吉洛症 (CAPA) 死亡率高达76.5%. 提高医疗意识和改进诊断对于管理这种严重的真菌共感染至关重要.
科学领域:
- 传染性疾病 传染性疾病
- 菌类学 菌类学是指菌类学.
- 关键护理医学 关键护理医学
背景情况:
- COVID-19是侵入性真菌感染的已知危险因素,特别是阿斯伯吉洛症.
- 严重的COVID-19病例需要进入重症监护室 (ICU) 的风险更高.
- 阿斯珀吉洛斯症复杂化了COVID-19,增加了发病率和死亡率.
研究的目的:
- 确定波兰ICU患者中COVID-19相关的肺性阿斯伯吉洛症 (CAPA) 的发生率和特征.
- 在这个人群中分析CAPA的诊断和治疗方法.
- 突出CAPA在重症COVID-19患者的临床影响和结果.
主要方法:
- 波兰克拉科夫专门的COVID-19ICU医疗记录的回顾性分析 (2021年5月 - 2022年1月).
- 纳入标准:在研究期间住院于ICU的患者.
- 收集的数据:发病率,孤立的真菌物种,诊断程序,抗真菌治疗和结果.
主要成果:
- 确定了17例CAPA病例,发病率密度为每10,000个患者日中的9例,总发病率为1%.
- 最常见的分离物是Aspergillus fumigatus和Aspergillus niger,这是最常见的分离物.
- 52.9%的患者接受了抗真菌治疗,主要是沃里康纳 (77.8%). 病例死亡率很高,为76.5%.
结论:
- 与COVID-19相关的肺阿斯伯吉洛症在ICU中构成重大威胁,死亡率非常高.
- 迫切需要提高医务人员对重症COVID-19患者的真菌共同感染的认识.
- 更有效地利用诊断和治疗工具对于改善CAPA患者的治疗结果至关重要.
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