相关实验视频

Updated: Jul 25, 2025

An Ex vivo Assay to Study Candida albicans Hyphal Morphogenesis in the Gastrointestinal Tract

An Ex vivo Assay to Study Candida albicans Hyphal Morphogenesis in the Gastrointestinal Tract

Published on: July 1, 2020

与COVID-19相关的侵入性真菌感染

Kyaw M Hlaing¹, Lea M Monday¹, Marcio Nucci²

¹Division of Infectious Diseases, Wayne State University School of Medicine, Detroit, MI 48201, USA.

Journal of fungi (Basel, Switzerland)

|June 27, 2023

概括

像侵入性阿斯伯吉洛症这样的真菌感染复杂化了严重的COVID-19,增加了死亡率. 早期诊断和抗真菌治疗对于重症患者的更好的治疗结果至关重要.

科学领域:

传染性疾病传染性疾病
关键护理医学关键护理医学
菌类学菌类学是指菌类学.

背景情况:

由于COVID-19的流行病导致了数百万人的死亡,通常是由于呼吸系统衰竭.
住院患者,特别是在重症监护室 (ICU),经历了严重的并发症.
菌感染,包括侵袭性阿斯伯吉洛症,候群病和粘菌菌,对发病率和死亡率做出了重大贡献.

研究的目的:

为了突出COVID-19患者中真菌感染的重大负担.
讨论与这些感染相关的风险因素和诊断挑战.
强调早期诊断和治疗的必要性,以改善患者的治疗结果.

主要方法:

关于COVID-19患者的真菌感染的临床数据和文献的审查.
风险因素的分析,包括病毒诱导的免疫变化和治疗性免疫抑制.
评估诊断局限性及其对患者管理的影响.

主要成果:

COVID-19患者,特别是那些在ICU中的患者,面临着侵入性真菌感染的高风险.
风险因素包括COVID-19对免疫防御和免疫抑制疗法的影响.
当前的诊断测试往往缺乏灵敏度,导致诊断延迟.
这些真菌感染的死亡率在某些患者队列中可以超过50%.

结论:

侵入性真菌感染对重症COVID-19患者构成严重威胁.
临床怀疑的高指数对于及时诊断至关重要.
早期启动适当的抗真菌治疗对于改善生存率至关重要.

关键词:

在 COVID-19 疫情中,阿斯珀吉洛斯症 (aspergillosis) 是一种疾病.候选症候群病是一种候选症.粘膜性肌肉病的发生.

更多相关视频

Author Spotlight: Advancing Research on Candida albicans Biofilm-Associated Prosthetic Joint Infections

Author Spotlight: Advancing Research on Candida albicans Biofilm-Associated Prosthetic Joint Infections

Published on: February 2, 2024

Bio-energetics Investigation of Candida albicans Using Real-time Extracellular Flux Analysis

Bio-energetics Investigation of Candida albicans Using Real-time Extracellular Flux Analysis

Published on: March 19, 2019

相关概念视频

Fungal Group Zygomycota

Fungal Group Zygomycota

Zygomycota, previously classified as a distinct fungal group, are primarily terrestrial, saprophytic molds that play a crucial role as decomposers. Recent phylogenetic studies have revealed that these fungi are now divided into two major clades — Mucoromycota, which includes many symbiotic species, and Zoopagomycota, which primarily consists of parasitic and pathogenic fungi. These groups exhibit distinct ecological roles and reproductive strategies while sharing key structural and...

Fungal Phylum Microsporidia

Fungal Phylum Microsporidia

Microsporidia are a group of obligate intracellular fungi that were initially classified as protists but were later reclassified based on phylogenetic, molecular, and structural evidence linking them to the Chytridiomycota. These unicellular, non-motile organisms are highly specialized parasites that infect a wide range of animal hosts, including humans. They have evolved extensive genomic and metabolic reductions, making them highly dependent on their hosts for survival.Morphology and Genomic...

Skin Diseases and Disorders

Skin Diseases and Disorders

Skin is the first line of defense and encounters a variety of microbes. Some pathogenic strains are often the cause of a broad range of infections of the skin and other body systems. These conditions can affect people of all ages and may have different causes, including genetic factors, infections, autoimmune reactions, environmental factors, and lifestyle choices.
Gram-positive Staphylococcus spp. and Streptococcus spp. are responsible for many of the most common skin infections. However, many...

Factors Affecting the Risk of Infection

Factors Affecting the Risk of Infection

The hosts' susceptibility to infection depends on several factors. The integrity of the skin and mucous membranes helps protect the body against microbial attacks. When the skin is altered, the chance of infection, limb loss, and even death increases.
The integrity and count of the white blood cells help the body resist pathogens and fight infection. When impaired, it reduces the body's resistance to pathogens. The acidic pH levels of the gastrointestinal, genitourinary tracts, and skin...

Endocarditis II: Clinical Features of Infective Endocarditis

Endocarditis II: Clinical Features of Infective Endocarditis

Endocarditis can present various clinical features depending on the causative organism and the patient's underlying health conditions. Initially, the clinical features of infective endocarditis develop gradually, presenting with nonspecific symptoms that can be easily mistaken for other illnesses.General SymptomsEarly symptoms of infective endocarditis are fever, chills, weakness, malaise, fatigue, and weight loss. These symptoms reflect the systemic nature of the infection and the body's...

Fungal Phylum Basidiomycota

Fungal Phylum Basidiomycota

Basidiomycota is a diverse phylum of fungi that includes ecologically significant decomposers such as white rot fungi, symbionts like mycorrhizal fungi, plant pathogens such as rusts and smuts, and edible species like Agaricus bisporus (the common button mushroom). These fungi play crucial roles in nutrient cycling, symbiotic relationships, and even human health. Their defining feature is the basidium, a microscopic club-shaped structure responsible for producing basidiospores.Fruiting Bodies...