对Aspergillus fumigatus子的肺炎反应的表征
Alexandra Bouyssi1, Tanguy Déméautis1, Alexis Trecourt1,2
1UR3738 Centre pour l'lnnovation en Cancérologie de Lyon, Team Inflammation and Immunity of the Respiratory Epithelium, Claude Bernard University-Lyon 1, 69495 Pierre Bénite, France.
Journal of fungi (Basel, Switzerland)
|June 27, 2023
概括
对Aspergillus fumigatus子 (AFsp) 的呼吸道暴露会在巨细胞和上皮细胞中引发显著的炎症反应. 这项研究证实了小鼠模型中的这些炎症发现,揭示了肺部组织学变化.
科学领域:
- 免疫学 免疫学 免疫学
- 肺部医学 肺部医学
- 微生物学 微生物学
背景情况:
- 对Aspergillus fumigatus子 (AFsp) 的呼吸道暴露可能导致炎症性肺部疾病.
- 了解宿主对慢性AFsp暴露的反应对于管理阿斯伯吉洛症至关重要.
研究的目的:
- 为了研究体外和体外宿主对慢性Aspergillus fumigatus子暴露的炎症反应.
- 分析底层的细胞和分子机制 AFsp诱导的炎症在肺组织.
主要方法:
- 使用小鼠巨细胞和膜上皮细胞单种和共同培养的体外研究.
- 在体内研究中,小鼠进行了AFsp的鼻内灌注,随后进行了肺组织学和支气管支气管洗分析.
主要成果:
- 在体外:AFsp暴露显著增加了巨细胞和一些上皮细胞中的促炎基因表达 (TNF-α,CXCL-1,CXCL-2,IL-1β,IL-1α,GM-CSF).
- 在共同培养中:观察到TNF-α,CXCL-2和CXCL-1的基因和蛋白质表达增加.
- 在体内:组织学分析揭示了肺组织中的细胞透;支气管支气管洗显示炎症媒介的蛋白质分泌量升高.
结论:
- 长期接触Aspergillus fumigatus子会在巨细胞和上皮细胞中引起显著的炎症反应.
- 这项研究证实了小鼠模型中的这些炎症反应,与可观察到的肺组织学变化相关.
相关概念视频
01:28Fungal Phylum Ascomycota
58
Phylum Ascomycota, a major division within the subkingdom Dikarya, comprises a diverse range of fungal species, including both unicellular yeasts and filamentous molds such as Aspergillus and Penicillium. These fungi thrive in a variety of habitats, from aquatic ecosystems to terrestrial environments, playing crucial ecological and economic roles.Morphology and ReproductionThe defining characteristic of Ascomycetes, commonly referred to as sac fungi, is the ascus—a sac-like structure that...
58
01:26Asthma-II: Pathophysiology and Classification
2.7K
Asthma is a prevalent chronic respiratory condition marked by inflammation and hyperresponsiveness of the airways. Its pathophysiology involves complex interactions among inflammatory pathways, immune responses, and neural mechanisms.
Additionally, environmental and genetic factors play crucial roles in determining an individual's susceptibility to asthma and the severity of their condition.
Critical processes in asthma pathophysiology include:
Additionally, environmental and genetic factors play crucial roles in determining an individual's susceptibility to asthma and the severity of their condition.
Critical processes in asthma pathophysiology include:
2.7K
01:20Asthma: Pathogenesis and Management
458
Asthma is a chronic pulmonary condition involving inflammation of the airways, hyper-reactivity, and reversible obstruction of the airways. This condition can significantly impact a person's quality of life, making breathing difficult and leading to distressing symptoms.
Asthma is classified as allergic and non-allergic. Allergens such as dust mites, pollen, and pet dander trigger allergic asthma, while factors like cold air, intense emotions, or exercise can induce non-allergic asthma.
Asthma is classified as allergic and non-allergic. Allergens such as dust mites, pollen, and pet dander trigger allergic asthma, while factors like cold air, intense emotions, or exercise can induce non-allergic asthma.
458
01:20COPD: Pathogenesis and Clinical Features
365
Chronic obstructive pulmonary disease (COPD) is a group of lung conditions that progressively worsen over time, including chronic bronchitis and emphysema. This cluster of diseases collectively leads to a gradual and irreversible decline in lung function over time.
The primary cause for the onset of COPD is cigarette smoking and exposure to air pollution. These hazardous factors initiate a chain reaction within the lungs, resulting in chronic inflammation, damage to the airways, and a...
The primary cause for the onset of COPD is cigarette smoking and exposure to air pollution. These hazardous factors initiate a chain reaction within the lungs, resulting in chronic inflammation, damage to the airways, and a...
365
01:29Pneumonia II: Pathophysiology
362
The pathophysiology of pneumonia involves the following steps:
362
01:28Pulmonary Tuberculosis II
281
Tuberculosis, or TB, is a bacterial infectious disease caused by Mycobacterium tuberculosis. While its primary impact is on the lungs, leading to pulmonary tuberculosis, it can also affect various other organs, a condition referred to as extrapulmonary tuberculosis.
Here is a detailed explanation of its pathophysiology:
Transmission: The process begins when a person inhales droplet nuclei containing M. tuberculosis. These are typically released into the air when an individual with pulmonary or...
Here is a detailed explanation of its pathophysiology:
Transmission: The process begins when a person inhales droplet nuclei containing M. tuberculosis. These are typically released into the air when an individual with pulmonary or...
281