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Menopause, a natural biological process marking the end of a woman's fertility, typically occurs between the fifth and sixth decade of life. This phase is characterized by the exhaustion of the ovarian follicle pool, leading to less responsive ovaries despite the high levels of Follicle Stimulating Hormone (FSH) and Luteinizing Hormone (LH). The consequential decrease in estrogen production results in symptoms like hot flashes, heavy sweating, headaches, hair loss, muscle pains, vaginal...
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Aging and its effect on bone remodeling is the most common cause of bone disorders. In young and healthy people, bone deposition and resorption happen at an equal rate to maintain optimal bone health.
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Several body functions deteriorate with age. The external signs of aging are easily identifiable. For example, the skin becomes dry, less elastic, and thins out, forming wrinkles. The skin of the face begins to appear looser due to a decrease in the levels of elastic and collagen fibers in the connective tissue. Additionally, melanin production in the hair follicle decreases with age, resulting in gray hair. Moreover, the senses of sight and hearing decline, so glasses and hearing aids may...
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在OAB老年女性患者尿液中的proBDNF/BDNF比率下降.

Claudia Covarrubias1, Philippe G Cammisotto1, Samer Shamout1

  • 1Lady Davis Institute, McGill University, Montreal, QC H3A 0G4, Canada.

Metabolites
|June 27, 2023
PubMed
概括

尿液中的proBDNF/BDNF比率可能有助于诊断老年妇女的过度活性膀 (OAB). 这一比率在OAB患者中较低,可能是由于MMP-9活性增加.

关键词:
这就是为什么BDNF是BDNF.在MMP-9中,它是MMP-9的.微RNAs 是一个微型RNA.过度活动的膀这是 proBDNF 的原因.蛋白质酶是一种蛋白质酶.尿液 尿液 尿液

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科学领域:

  • 神经科学是一个神经科学.
  • 泌尿器科 泌尿器科 泌尿器科 泌尿器科
  • 生物化学 生物化学

背景情况:

  • 像BDNF这样的神经营养素对神经元健康至关重要,并且在疾病中经常失衡.
  • 过度活跃的膀 (OAB) 是一种常见的疾病,影响着老年人群.

研究的目的:

  • 为了研究大脑衍生神经营养因子 (BDNF) 和其前体 (proBDNF) 的尿液水平,在老年女性中患有OAB.
  • 探索proBDNF/BDNF比率的诊断潜力及其与OAB严重程度和潜在机制的关系.

主要方法:

  • 来自老龄化女性OAB患者和健康对照者的尿液样本被分析为proBDNF和BDNF度.
  • 进行了肌素正常化,proBDNF/BDNF比率计算,ROC曲线分析和与症状得分 (OABSS,IIQ-7) 的相关性.
  • 评估了尿基金属蛋白酶-9 (MMP-9) 活性和miR-491-5p水平.

主要成果:

  • 虽然总BDNF和proBDNF水平相似,但OAB患者的proBDNF/BDNF比率明显较低 (AUC = 0.729).
  • 减少的proBDNF/BDNF比率与增加的OAB症状严重程度相关.
  • 在OAB中,尿液中的MMP-9活性升高,而miR-491-5p水平降低,表明增强了proBDNF分裂.

结论:

  • 泌尿中的proBDNF/BDNF比率显示为老年妇女OAB表型的生物标志物具有前途.
  • 较高的MMP-9活性,而不是翻译控制,似乎驱动了OAB中改变的proBDNF/BDNF比率.