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在OAB老年女性患者尿液中的proBDNF/BDNF比率下降
Claudia Covarrubias1, Philippe G Cammisotto1, Samer Shamout1
1Lady Davis Institute, McGill University, Montreal, QC H3A 0G4, Canada.
Metabolites
|June 27, 2023
概括
尿液中的proBDNF/BDNF比率可能有助于诊断老年妇女的过度活性膀 (OAB). 这一比率在OAB患者中较低,可能是由于MMP-9活性增加.
科学领域:
- 神经科学是一个神经科学.
- 泌尿器科 泌尿器科 泌尿器科 泌尿器科
- 生物化学 生物化学
背景情况:
- 像BDNF这样的神经营养素对神经元健康至关重要,并且在疾病中经常失衡.
- 过度活跃的膀 (OAB) 是一种常见的疾病,影响着老年人群.
研究的目的:
- 为了研究大脑衍生神经营养因子 (BDNF) 和其前体 (proBDNF) 的尿液水平,在老年女性中患有OAB.
- 探索proBDNF/BDNF比率的诊断潜力及其与OAB严重程度和潜在机制的关系.
主要方法:
- 来自老龄化女性OAB患者和健康对照者的尿液样本被分析为proBDNF和BDNF度.
- 进行了肌素正常化,proBDNF/BDNF比率计算,ROC曲线分析和与症状得分 (OABSS,IIQ-7) 的相关性.
- 评估了尿基金属蛋白酶-9 (MMP-9) 活性和miR-491-5p水平.
主要成果:
- 虽然总BDNF和proBDNF水平相似,但OAB患者的proBDNF/BDNF比率明显较低 (AUC = 0.729).
- 减少的proBDNF/BDNF比率与增加的OAB症状严重程度相关.
- 在OAB中,尿液中的MMP-9活性升高,而miR-491-5p水平降低,表明增强了proBDNF分裂.
结论:
- 泌尿中的proBDNF/BDNF比率显示为老年妇女OAB表型的生物标志物具有前途.
- 较高的MMP-9活性,而不是翻译控制,似乎驱动了OAB中改变的proBDNF/BDNF比率.
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