营养干预作为一种补充的神经保护方法,用于对抗 Propionic 酸诱导的神经毒性和关联的生化自闭特征
Sana Razhan M Alsubaiei1, Hanan A Alfawaz1, Ramesa Shafi Bhat2
1Department of Food Science and Nutrition, College of Food & Agriculture Sciences, King Saud University, Riyadh 11495, Saudi Arabia.
Metabolites
|June 27, 2023
概括
益生菌和桃等食补充剂在减轻自闭症谱系障碍 (ASD) 风险方面表现有前途. 这些干预措施有助于在老鼠模型中减少氧化应激和神经炎症,这表明在ASD预防方面可能发挥作用.
科学领域:
- 神经科学是一个神经科学.
- 生物化学 生物化学
- 营养科学 营养科学
背景情况:
- 自闭症谱系障碍 (ASD) 是一个日益关注的问题,没有已知的治疗方法,通常伴随着胃肠道问题影响行为.
- 识别风险和保护因素对于有效的ASD预防和干预策略至关重要.
- 饮食干预有兴趣,但最佳营养疗法仍在争论中.
研究的目的:
- 在大鼠模型中评估酸 (PPA) 暴露的神经毒性影响.
- 评估益生菌和益生菌对PPA诱导的变化的保护作用.
- 研究特定食补充剂对与ASD相关的氧化应激和神经炎症标志物的生物化学影响.
主要方法:
- 使用了一种老鼠模型,36只雄性Sprague Dawley白色老鼠幼被分成六组.
- 一组作为对照,另一个接受PPA诱导ASD模型.
- 在PPA注射之前,四组每天服用酸奶,花粉,黄素或*Lacticaseibacillus rhamnosus* GG,然后对GABA,GPX1,GSH,IL-6,IL-10和TNF等标记物进行大脑同质物的生物化学分析.
主要成果:
- 与对照组相比,PPA诱导的模型表现出较高的氧化应激和神经炎症.
- 所有四种经过测试的饮食疗法 (酸奶,花生,黄素,乳酸乳酸菌 (Lacticaseibacillus rhamnosus) GG) 都显示出生物化学标记的显著改善.
- 这些改善表明,在接受饮食干预的PPA治疗的老鼠中,氧化应激和神经炎症减少.
结论:
- 经过测试的饮食疗法具有显著的抗炎和抗氧化特性.
- 这些补充剂可以作为预防自闭症谱系障碍的有价值的饮食成分.
- 对营养策略的进一步研究对于ASD的管理和预防是有必要的.
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