相关实验视频
Updated: Jul 25, 2025

12:59
Isolation and Th17 Differentiation of Naïve CD4 T Lymphocytes
Published on: September 26, 2013
34.6K
在自身免疫和感染中出现了明显的炎症Th17子集
Ronald J Bouch1,2, Jing Zhang1, Brandi C Miller1,2
1Department of Microbiology and Immunology, Wake Forest School of Medicine, Winston-Salem, NC, USA.
The Journal of experimental medicine
|June 27, 2023
概括
研究人员确定了两种不同的炎症T辅助17 (Th17) 细胞子集. 克洛法齐明选择性地抑制亲自身免疫Th17细胞,为治疗自身免疫性疾病提供了潜在的潜力.
科学领域:
- 免疫学 免疫学 免疫学
- 细胞生物学 细胞生物学
- 药理学 药理学是指药理学的学科.
背景情况:
- 辅助性T17 (Th17) 细胞对于宿主防御和自身免疫性疾病至关重要.
- 了解炎症Th17细胞的不同作用仍然是一个挑战.
- 驱动炎症Th17细胞不同功能的机制尚不清楚.
研究的目的:
- 为了区分涉及自身免疫性大肠炎和感染的炎症性Th17细胞群.
- 调查这些人群对克洛法齐明 (CLF) 的差异反应.
- 探索CLF在选择性抑制亲自身免疫Th17细胞中的机制.
主要方法:
- 从自身免疫性结肠炎和感染模型中对Th17细胞群的比较分析.
- 对克洛法齐明 (CLF) 的差异反应的评估.
- 通过CLF研究ALDH1L2在Th17细胞调节中的作用.
主要成果:
- 在自身免疫性结肠炎和感染中,炎症性Th17细胞是可区分的群体.
- 克洛法齐明 (CLF) 选择性地抑制亲自身免疫Th17细胞.
- 通过减少ALDH1L2.2,CLF保留了感染引起的Th17细胞功能,部分原因是通过减少ALDH1L2.
- 在炎症Th17区间内,两个不同的子集表现出独特的调节机制.
结论:
- 炎症Th17细胞包括不同的子集,具有不同的调节途径.
- 克洛法齐明 (CLF) 显示出作为亲自身免疫Th17细胞的选择性抑制剂的潜力.
- 针对促进疾病的Th17细胞提供了针对自身免疫性疾病的治疗策略.
相关概念视频
T Cell Types and Functions
1.1K
When T cells with CD4 markers are activated, they give rise to two types of effector cells: helper T cells and regulatory T cells. Meanwhile, T cells with CD8 markers differentiate into effector cytotoxic T cells. The differentiation of CD4 T cells into helper T cell subsets, such as Th1, Th2, and Th17 cells, is dependent on the antigen type, antigen-presenting cell, and regulatory cytokines.
Th1 cells stimulate dendritic cells to express necessary co-stimulatory molecules on their surfaces for...
Th1 cells stimulate dendritic cells to express necessary co-stimulatory molecules on their surfaces for...
1.1K
Inflammatory Response
2.2K
An inflammatory response is a localized, nonspecific immune reaction that occurs when a tissue is injured. It is characterized by redness, swelling, heat, and pain, which are commonly called the cardinal signs and symptoms of inflammation. Inflammation can sometimes result in a loss of function.
Inflammation can be triggered by various stimuli, such as impact, abrasion, chemical irritation, infections, and extreme hot or cold temperatures. These can damage cells and connective tissue fibers,...
Inflammation can be triggered by various stimuli, such as impact, abrasion, chemical irritation, infections, and extreme hot or cold temperatures. These can damage cells and connective tissue fibers,...
2.2K
Autoimmune Disorders
526
Autoimmune diseases are a group of disorders in which the body's immune system mistakenly attacks its own cells, tissues, and organs. This results from an overactive immune response against substances and tissues normally present in the body. Let's delve into the concept and mechanism of autoimmune diseases from an immune system point of view, explore different causes and examples of such diseases, and discuss potential solutions.
Concept and Mechanism of Autoimmune Diseases
The immune...
Concept and Mechanism of Autoimmune Diseases
The immune...
526
Inflammatory Response I: Vascular and Cellular
11.5K
The inflammatory response is the body's defense against infection, injury, or irritation from bacteria, trauma, toxins, or heat. Inflammation helps locate and destroy pathogens and remove damaged tissue elements to heal the body. During this initial phase, fluid, blood products, and nutrients migrate to the injured area, resulting in redness, heat, swelling, ache, and loss of function. Moreover, signs of systemic inflammation include fever, increased WBC count, malaise, anorexia, nausea,...
11.5K
Immune Response Against Viral Pathogens
830
The immune system's response to viral infections is a complex and coordinated process involving natural killer (NK) cells, T cell-mediated responses, and antibody-mediated responses.
NK Cells
NK cells are a crucial part of our innate immune system, acting as the first line of defense against viral infections. These cells can recognize and kill infected cells without prior exposure to the virus, effectively slowing down the spread of infection. Additionally, NK cells produce proinflammatory...
NK Cells
NK cells are a crucial part of our innate immune system, acting as the first line of defense against viral infections. These cells can recognize and kill infected cells without prior exposure to the virus, effectively slowing down the spread of infection. Additionally, NK cells produce proinflammatory...
830
Antigens Involved in Adaptive Immunity
563
An antigen is any substance the immune system identifies as foreign and potentially harmful to the body, prompting an immune response. Antigens have two functional properties: immunogenicity and reactivity. Immunogenicity is the ability of an antigen to stimulate a specific immune response. At the same time, reactivity describes the antigen's ability to react with the cells and antibodies produced in response to it.
Complete Antigens
Complete antigens possess both immunogenicity and...
Complete Antigens
Complete antigens possess both immunogenicity and...
563

