针对神经性下尿路功能障碍 (NAPRUN) 中复发性尿路感染的非抗生素预防:为前性,纵向多臂观察性研究进行研究协议
Fabian P Stangl1, Laila Schneidewind2, Bernhard Kiss1
1Department of Urology, University Hospital of Bern, 3010 Bern, Switzerland.
Methods and protocols
|June 27, 2023
概括
这项研究比较了在接受间歇性自导管治疗的神经性下尿路功能障碍 (NLUTD) 患者中预防复发性尿路感染 (rUTIs) 的非抗生素预防. 它评估了各种非抗生素选择的有效性,以减少感染率和改善患者的治疗结果.
科学领域:
- 泌尿器科 泌尿器科 泌尿器科 泌尿器科
- 传染性疾病 传染性疾病
- 临床药理学 临床药理学
背景情况:
- 使用间歇性自导管的神经性下尿路功能障碍 (NLUTD) 患者面临复发性尿路感染 (rUTIs) 的高风险.
- 目前的预防策略,如抗生素预防,有助于抗菌素耐药性.
- 迫切需要有效的非抗生素替代品来预防这种脆弱人群中的RUTIs.
研究的目的:
- 为了比较不同非抗生素预防方案的临床有效性,以预防RUTIs.
- 评估NLUTD患者中突破性感染的发生率,这些患者实行间歇性自导管.
- 评估二次结果,包括不良事件和感染严重程度.
主要方法:
- 这是一项多中心,前性,纵向,多臂的观察性研究,包括785名NLUTD患者进行间歇性自导管.
- 患者接受了非抗生素预防,包括UroVaxom®,StroVac®,Angocin®,D-曼诺斯或盐水膀灌.
- 随访时间为12个月,主要结果是突破性感染发生率和二次结果,包括不良事件和感染严重程度.
主要成果:
- 这项研究正在进行中,结果正在等待发表.
- 数据收集的重点是突破性感染和相关不良事件的发生率.
- 分析还将探索微生物易感性模式的变化和与健康有关的生活质量.
结论:
- 这项研究旨在提供关于非抗生素预防在NLUTD患者中预防RUTI的比较有效性的关键数据.
- 这些发现将通过确定抗生素预防的安全和有效替代品来为临床实践提供信息.
- 这项研究解决了在依赖间歇性自导管治疗的患者中管理复发性感染的关键未满足需求.
关键词:
安戈辛辛 (Angocin) 是一种神经疾病.D-曼诺糖的使用方法在NLUTD中,它是NLUTD.这就是StroVac.在UroVaxomom中使用.膀灌 膀灌 是一种非抗生素预防的预防.自己导管的自导管.尿路功能障碍 尿路功能障碍尿路感染 尿路感染更多相关视频
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