ангиотензин II 和登革热的作用
Jesus A Mosquera-Sulbaran1, Adriana Pedreañez2, Juan Pablo Hernandez-Fonseca3,4
1Instituto de Investigaciones Clínicas "Dr. Américo Negrette", Facultad de Medicina, Universidad del Zulia, Maracaibo, 4001-A, Venezuela. mosquera99ve@yahoo.com.
Archives of virology
|June 27, 2023
概括
本综述探讨了激素 ангиотензин II (Ang II) 在登革热病变发生过程中的潜在作用. 有证据表明,Ang II可能通过影响炎症和凝血导致严重登革热.
科学领域:
- * 传染病和病毒学
- * 心血管生理学 * 心血管生理学
- * 免疫学和炎症学
背景情况:
- *由Aedes蚊子传播的登革热病毒感染是全球重要的健康问题.
- *严重的登革热与细胞因子风暴,氧化应激和凝血异常有关.
- * ангиотензинII (AngII),是氨酸- ангиотензин系统的关键组成部分,已知调节炎症和血管过程.
研究的目的:
- * 审查登革热感染的病理生理学.
- * 检查 ангиотензин II 在各种疾病状态中已确定的作用.
- * 综合证据表明Ang II在登革热病原发生过程中的潜在参与.
主要方法:
- * 对登革热病理生理学研究的综合文献综述.
- *对 ангиотензинII对心血管和炎症疾病影响的研究分析.
- *评估间接证据,将Ang II与登革热相关机制联系起来.
主要成果:
- * ангиотензин II 可以刺激促炎性细胞因子的产生.
- * Ang II 影响参与凝血和血管透性的途径.
- *现有的数据间接支持Ang II对登革热严重表现的潜在贡献.
结论:
- *虽然没有直接证实,但已知的 angiotensin II 的功能表明它可能在严重的登革热中发挥作用.
- * 需要进一步的研究,以阐明Ang II对登革热病变的直接影响.
- * 准Ang II通路可能代表严重登革热的新疗法策略.
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