阿尔法上腺素受体阻塞对绝经后妇女冠状动脉循环的影响
Maitê L Gondim1, Helena N M Rocha1,2, Pedro A C Mira1
1Laboratory of Exercise Science, Department of Physiology and Pharmacology, Fluminense Federal University, Niterói, Brazil.
European journal of applied physiology
|June 27, 2023
概括
阿尔法1-上腺体受体阻塞对年轻女性和绝经后妇女的冠状动脉循环有不同的影响. 绝经后的妇女表现出冠状动脉血管运动控制受损,而不是由α1-上腺素受体介导.
科学领域:
- 心血管生理学心血管生理学
- 自主神经系统的自主神经系统
- 血管生物学 血管生物学
背景情况:
- 冠状动脉循环调节对于心脏功能至关重要.
- 血液循环自主控制的与年龄相关的变化尚未完全理解.
- 阿尔法1-上腺素受体在血管度中起作用.
研究的目的:
- 调查α1-上腺素受体阻塞在各种生理压力因素期间对冠状动脉循环的影响.
- 为了比较年轻女性和绝经后妇女之间的反应.
主要方法:
- 10名年轻女性和9名绝经后妇女参与了这项研究.
- 使用了两种方案:冷压力测试 (CPT) 和手握运动 (Grip) 与代谢反射激活 (Metabo) 联合.
- 测量是在控制条件下进行的,并在用prazosin阻断α1-上腺素受体后进行测量.
主要成果:
- 绝经后妇女的冠状动脉血液速度和导电率较低.
- 在任何一组中,α1-阻塞都没有改变冠状动脉血液速度对Grip的反应.
- CPT仅在阿尔法1阻塞后的年轻女性中增加了冠状动脉血液速度,这表明在这个群体中发挥了作用.
- 在两组所有压力因素期间,冠状动脉血管导电量都下降了,但封锁仅在年轻女性中阻止了这种下降.
结论:
- 阿尔法1-上腺体受体影响年轻女性的冠状动脉循环控制,在CPT期间与Grip和Metabo相比,血管收缩作用更为明显.
- 绝经后妇女表现出冠状动脉血管运动控制受损,这似乎独立于α1-上腺素受体活性.
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