预测微切割丸精子提取结果的阿佐精子患者的化学疗法后使用环胺等效剂量使用环胺
Shi-Jie Tsai1, Li-Hua Li2,3, Wei-Jen Chen1,4
1Department of Urology, Taipei Veterans General Hospital, No. 201, Section 2, Shipai Rd, 112, Taipei, Taiwan.
Journal of assisted reproduction and genetics
|June 27, 2023
概括
在化学疗法后患有亚精子症的男性中,精子检索率较低,特别是在使用化剂时. 较高的环胺等效剂量 (CED) 显著降低了成功取精的机会,建议在接受密集治疗的患者中谨慎行事.
科学领域:
- 生殖医学 生殖医学
- 在瘤学瘤学.
- 遗传学 是一个遗传学.
背景情况:
- 化疗,特别是化剂,可以导致持续的亚精精.
- 评估化疗剂量对精子检索的影响对于生育保护咨询至关重要.
研究的目的:
- 为了确定化学治疗后持久性阿佐精子症男性的精子检索率.
- 评估循环胺等效剂量 (CED) 与精子采集成功之间的关系.
主要方法:
- 对1098名患有非阻塞性亚精子症的患者进行了回顾性审查,这些患者接受了微切割丸精子提取 (mTESE).
- 对23名先前接受过化疗的患者的分析,包括瘤学数据,化疗方案,剂量 (CED) 和mTESE结果.
主要成果:
- 在47%的患者 (11/23) 中,精子提取成功.
- 暴露于化剂的患者的精子检索率显著降低 (11%vs71%).
- 在CED>4000 mg/m2时没有发生精子提取;较高的CED与较低的成功率相关.
结论:
- 以基化剂为基础的化疗降低了永久性亚精子症的男性的丸精子检索率.
- 较高的累积化疗剂量 (CED) 表示精子获取成功的可能性较低.
- 在进行手术之前,建议使用CED模型对精子采集结果的患者进行咨询.
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