列表模式重建和图像空间点差函数校正对使用基于SiPM的PET/CT系统对PET图像对比度和定量值的影响
Yuya Shirakawa1, Norikazu Matsutomo2
1Department of Radiology, Kyorin University Hospital, 6-20-2 Shinkawa, Mitaka, Tokyo, 181-8611, Japan. yuya_shirakawa@ks.kyorin-u.ac.jp.
Radiological physics and technology
|June 27, 2023
概括
这项研究评估了列表模式重建和图像空间点扩散函数 (iPSF) 如何影响正子发射断层扫描 (PET) 图像质量. 虽然iPSF对对比度的影响很小,但它提高了定量准确性,并减少了PET/CT扫描中的文物.
科学领域:
- 医疗成像医学成像
- 核医学就是核医学.
- 射线物理学 射线物理学
背景情况:
- 定子发射断层扫描 (PET) 成像依赖于精确的图像重建以进行定量分析.
- 图像空间点分布函数 (iPSF) 建模是一种提高PET图像分辨率和定量化的技术.
- 了解iPSF对PET/CT图像质量的影响对于临床应用至关重要.
研究的目的:
- 评估列表模式重建和iPSF对PET/CT图像对比度和定量值的影响.
- 评估iPSF对图像工件和标准化摄入值 (SUV) 等临床指标的影响.
- 确定iPSF对信号与背景比率 (SBR) 和背景可变性的影响.
主要方法:
- 使用Cartesion Prime SiPM-PET/CT系统进行数据采集.
- 采用3D-OSEM重建与飞行时间,iPSF (+/-) 和高斯过.
- 使用NEMA身体幻影数据在各种SBR和临床肺结节图像中评估图像质量.
主要成果:
- iPSF对背景变化的影响有限,但在不同的SBR中对比度增加 (QH,10mm).
- iPSF引入了超越文物,特别是在较小的球体中,在更高的代和SBR中增加了严重性.
- 用iPSF减少了边缘人工物,在临床图像中,SUV和肝脏SNR都显著改善.
结论:
- 列表模式重建和iPSF对PET图像对比度的影响有限.
- iPSF提高了定量准确性,并减少了PET/CT成像中的边缘工件,尽管可能会超标.
- 在SiPM-PET/CT中,iPSF调整有利于提高临床图像质量和定量分析.
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