与乙型肝炎病毒相关的肝脏内胆管癌起源于肝细胞
Zimin Song1, Shuirong Lin1, Xiwen Wu1,2
1Center of Hepato-Pancreato-Biliary Surgery, The First Affiliated Hospital of Sun Yat-Sen University, Guangzhou, 510030, China.
Hepatology international
|June 27, 2023
概括
乙型肝炎病毒 (HBV) 感染与肝脏内胆管癌 (ICC) 有关. 这项研究表明,在感染HBV的患者中,ICC可能来自肝细胞,而不是胆管,这些患者也表现出较差的生存结果.
科学领域:
- 肝病学和瘤学 肝病学和瘤学
- 病毒性肝炎研究研究
- 癌症的发病因子 癌症的发病因子
背景情况:
- 乙型肝炎病毒 (HBV) 感染是肝脏内胆管癌 (ICC) 的已知危险因素.
- 将HBV感染与ICC发展联系起来的直接因果关系证据仍然有限.
- 这项研究使用有机体模型研究HBV相关的ICC的细胞起源.
研究的目的:
- 为了确定肝脏内胆管癌 (ICC) 是否起源于乙型肝炎病毒 (HBV) 感染患者的肝细胞.
- 探索HBV感染对ICC患者预后的影响.
- 在ICC组织和衍生器官中研究HBV抗原的细胞定位和表达.
主要方法:
- 追溯分析了182个ICC患者记录和瘤组织.
- 免疫组织化学 (IHC) 和免疫光 (IF) 染色用于HBsAg,CK19,CK7,Hep-Par1和白蛋白 (ALB).
- 产生和分析ICC组织衍生器官,包括在培养基中检测HBV-DNA.
主要成果:
- 在40.66%的ICC患者中检测到乙型肝炎表面抗原 (HBsAg).
- 在HBV阳性 (HBV+) ICC组织和器官中,HBsAg的表达局部化到瘤细胞,而不是胆道细胞.
- 感染HBV的肝细胞显示HBs抗原和HBx的表达高于胆道上皮细胞.
- 与HBV (-) 患者相比,HBV (+) ICC患者的无病生存期 (DFS) 显着较短.
- 在HBV (+) 器官的培养基中检测到高水平的HBV-DNA.
结论:
- 在乙型肝炎病毒 (HBV) 感染的背景下,肝脏内胆管癌 (ICC) 可能起源于肝细胞.
- 乙型肝炎病毒 (HBV) 阳性 (HBV+) 内肝胆管癌 (ICC) 与较差的无病生存率 (DFS) 有关.
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