基于增加带宽的方法,使单粒子ICP-MS中使用内部标准成为可能:适用于AuNP的表征
Antonio Bazo1, Maite Aramendía1, Flávio V Nakadi1
1Department of Analytical Chemistry, Aragón Institute of Engineering Research (I3A), University of Zaragoza, Pedro Cerbuna 12, 50009 Zaragoza, Spain.
Nanomaterials (Basel, Switzerland)
|June 27, 2023
概括
本研究引入了一种新的方法,用于单颗粒感应合等离子体质谱学 (SP ICP-MS) 中的内部标准校正,使用纳米粒子 (PtNPs) 作为金纳米粒子 (AuNP) 表征的内部标准.
科学领域:
- 分析化学 分析化学
- 纳米技术纳米技术
- 材料科学 材料科学 材料科学
背景情况:
- 对复杂矩阵中纳米粒子的准确表征对于各种应用至关重要.
- 矩阵效应可以显著影响SP ICP-MS中的纳米粒子检测灵敏度和运输效率.
- 在SP ICP-MS中进行内部标准校正的现有方法在复杂的样本环境中存在局限性.
研究的目的:
- 开发和验证用于单粒子感应合等离子体质谱学 (SP ICP-MS) 的新型内部标准 (IS) 校正方法.
- 为了使金纳米颗粒 (AuNPs) 在复杂矩阵中使用纳米颗粒 (PtNPs) 作为IS的准确表征.
- 在SP ICP-MS.中提高纳米粒子分析的灵活性和灵活性.
主要方法:
- 在带通模式中使用质谱仪,以提高灵敏度和同时检测AuNPs和PtNPs.
- 采用粒子大小方法来确定纳米粒子大小,以及动态质量流方法来确定粒子数度 (PNC).
- 在三个不同的矩阵中验证了该方法:纯水,NaCl溶液和TMAH/Triton X-100溶液.
主要成果:
- 建议的IS校正方法与带宽模式相结合,有效地弥补了对灵敏度和运输效率的矩阵效应.
- 在所有测试的复杂矩阵中实现了AuNPs的精确大小和PNC确定.
- 证明了对AuNPs和PtNPs的同时检测,对于每个纳米粒子类型都有可调节的灵敏度.
结论:
- 在带通模式中使用 PtNP 的新型 IS 校正方法为 SP ICP-MS 中精确的纳米粒子表征提供了强大的解决方案.
- 这种方法显著提高了纳米粒子分析在复杂的环境和工业样本的可靠性.
- 带通模式为解决纳米粒子分布提供了增强的分析灵活性.
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