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从长期COVID治疗认知缺陷的科学理由
Arman Fesharaki Zadeh1,2, Amy F T Arnsten3, Min Wang3
1Departments of Neurology, Yale University School of Medicine, New Haven, CT 06510, USA.
Neurology international
|June 27, 2023
概括
长期的COVID会通过增加大脑中的金酸 (KYNA) 和GCPII而导致认知缺陷. 通过向这些途径,N-乙半氨酸和guanfacine可能会恢复认知功能.
科学领域:
- 神经科学是一个神经科学.
- 免疫学 免疫学 免疫学
- 药理学 药理学是指药理学的学科.
背景情况:
- 长期的COVID与持续的认知缺陷有关,特别是在背侧前额皮层 (dlPFC) 功能,如工作记忆和执行功能.
- 在COVID-19感染时,大脑的基努伦酸 (KYNA) 和谷氨酸碳酸酶II (GCPII) 升高,这会损害dlPFC的神经传递和网络连接.
研究的目的:
- 探索长期COVID相关认知功能障碍的潜在治疗剂.
- 调查KYNA和GCPII在dlPFC减弱中的作用.
- 为了确定可能恢复dlPFC生理学的现有药物.
主要方法:
- 关于长期COVID认知缺陷的现有文献的审查.
- 在PFC中分析涉及KYNA和GCPII的生化途径.
- 对N-乙半氨酸 (NAC) 和guanfacine进行评估,以评估它们对抗这些影响的潜力.
主要成果:
- KYNA阻断NMDA和尼古丁α-7受体,这对dlPFC神经传递至关重要.
- GCPII破坏了mGluR3信号通路的调节,削弱了dlPFC连接和神经元发射.
- NAC抑制KYNA的产生,而guanfacine调节信号通路,并具有抗炎性质.
结论:
- 在治疗长期COVID认知症状方面,N-乙半氨酸和guanfacine显示出有前途.
- 准KYNA和GCPII通路可能是恢复dlPFC功能的可行策略.
- 需要进一步的研究来验证这些药物对长期COVID认知障碍的有效性.
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