肠道微生物群及其对帕金森病的影响:西方患者的系统性审查
Ana Cristina Proano1, Javier A Viteri2, Eileen N Orozco3
1School of Medicine, Universidad Internacional del Ecuador, Quito 170411, Ecuador.
Neurology international
|June 27, 2023
概括
帕金森病 (PD) 与西方人群的肠道微生物群失调有关. 与对照组相比,在PD患者中观察到细菌群体的显著变化,突出显示了肠道微生物组在PD中的作用.
科学领域:
- 微生物学 微生物学
- 神经科学是一个神经科学.
- 胃肠病学 胃肠病学
背景情况:
- 帕金森病 (PD) 是一种复杂的神经退行性疾病,其机制尚未完全理解.
- 肠道微生物群的变化越来越多地与各种疾病的病理生理学有关.
- 肠道功能失调可能在帕金森病的发展和进展中发挥作用.
研究的目的:
- 系统地审查和比较来自西方地区的帕金森病患者肠道微生物群的数据.
- 为了确定帕金森病和肠道微生物群失调症之间的重要关联.
- 分析与帕金森病相关的肠道微生物变化的地理差异.
主要方法:
- 按照PRISMA和MOOSE协议进行系统审查.
- 在PubMed上进行了文献搜索,选择了10项符合纳入标准的病例控制研究 (西方地区,人类受试者,英语,PD和肠道微生物组相关性).
- 纽卡斯尔-太华尺度用于偏差风险评估.
主要成果:
- 在三个分析区域 (北美,北欧/中欧,意大利) 的帕金森病患者中观察到肠道细菌种群的显著变化.
- 在Actinobacteriota (Bifidobacterium),Verrucomicrobiota (Akkermansia),Firmicutes (Enterococcus,Lactobacillus),Bacteroidetes和Proteobacteria中发现了特定的增加.
- 在患有帕金森病的患者中观察到Firmicutes (Lachnospiraceae,Blautia,Roseburia,Ruminococcus) 和Bacteroidetes (Prevotella) 的减少.
结论:
- 在来自西方地区的帕金森病患者中明显出现了显著的肠道失调.
- 多种细菌系参与了在帕金森病中观察到的肠道微生物组变化.
- 需要进一步的研究来阐明其他微生物 (如真菌和寄生虫) 在帕金森病病原体中的作用.
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