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在超重的年轻男性中,腹部下部脂肪组织大麻素1型受体的可用性

Laura Pekkarinen^1,2, Tatu Kantonen^1,3, Vesa Oikonen¹

¹Turku PET Centre, University of Turku, Turku, Finland.

Obesity (Silver Spring, Md.)

|June 27, 2023

概括

在肥胖风险较高的男性中,腹部脂肪中的大麻素1型受体 (CB1R) 可用性较低. 这表明,在肥胖前,内分泌系有失调.

科学领域:

内分泌学在内分泌学.
神经科学是一个神经科学.
代谢过程中的代谢.

背景情况:

大麻素1型受体 (CB1R) 在调节养行为和能量平衡方面发挥着至关重要的作用.
在肥胖中,CB1R信号传递往往失调,影响能量恒温.
研究外围组织和大脑中的CB1R可用性是了解肥胖发展的关键.

研究的目的:

为了比较CB1R在周围组织和大脑中的可用性,在超重的年轻男性 (肥胖风险高) 和瘦男 (肥胖风险低) 之间进行比较.
探索CB1R可用性,胰岛素敏感性和与肥胖风险相关的代谢标志物之间的关系.

主要方法:

利用-18标记的FMPEP-d2正电子发射断层扫描来量化CB1R在腹部脂肪组织,棕色脂肪组织,肌肉和大脑中的可用性.
通过BMI,运动习惯和家庭病史来评估肥胖风险.
测量胰岛素敏感性使用-18-脱氧-2-D-葡萄糖正子发射断层扫描在高胰岛素-高血糖.

主要成果:

与低风险组相比,高风险组的CB1R在腹部脂肪组织中的可用性明显较低.
在其他研究的组织中没有观察到CB1R可用性的差异.
在腹部脂肪和大脑中的CB1R可用性与胰岛素敏感性正相关,与BMI,脂肪和炎症标志物负相关.

结论:

研究结果表明,内分泌大麻素系统的调节失调,特别是腹部脂肪中的CB1R可用性降低,可能是前肥胖症的早期指标.
这突显了内分泌大麻素系统在肥胖发展中的潜在作用.

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