在艾滋病毒缓解试验中无法消除传播风险时,对信任的基本需求
Stuart Rennie1, Gail Henderson2, Nittaya Phanuphak3
1Professor at the Center for Bioethics in the Department of Social Medicine at the University of North Carolina at Chapel Hill.
Ethics & human research
|June 27, 2023
概括
在艾滋病毒缓解研究中,分析性治疗中断 (ATI) 是必要的,但有风险. 建立信任和可信度对于这些试验的伦理和成功进行至关重要,因为无法完全消除传播风险.
科学领域:
- 艾滋病毒/艾滋病研究研究
- 临床试验的伦理学
- 传染病管理 传染病管理
背景情况:
- 分析性治疗中断 (ATI) 对于评估艾滋病缓解策略至关重要.
- 在ATI期间停止抗逆转录病毒治疗可能会给参与者和伴侣传播艾滋病毒的风险.
- 目前的伦理讨论重点是降低风险和利益相关者的责任.
研究的目的:
- 检查艾滋病毒缓解试验中ATI的伦理复杂性.
- 探索信任和可信度在管理不可消除的传播风险中的作用.
- 分析风险减轻和责任框架的优势和局限性.
主要方法:
- 对泰国涉及ATI的HIV缓解试验的经验进行定性分析.
- 检查围绕风险减轻和参与者安全的伦理辩论.
- 在临床研究环境中探索基于信任的方法.
主要成果:
- 在ATI期间传播艾滋病毒的可能性实际上是不可消除的.
- 风险减轻和责任方法具有固有的复杂性和局限性.
- 信任和可信度对于提高ATI试验的科学,实践和道德行为至关重要.
结论:
- 成功的艾滋病毒缓解试验与ATI基本上取决于建立信任和可信度.
- 伦理行为需要通过强大的关系基础承认和管理不可避免的风险.
- 未来的研究应该优先考虑建立和保持对敏感临床试验的信任.
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